{"title":"二甲亚砜通过调节关键生命周期性状抑制禾谷镰刀菌致病性。","authors":"Taiying Li, Seunghyun Lee, Taewon Choi, Yurim Lim, Tianling Ma, Jungkwan Lee","doi":"10.5423/PPJ.OA.06.2025.0074","DOIUrl":null,"url":null,"abstract":"<p><p>Dimethyl sulfoxide (DMSO) is widely recognized for its versatile solvent properties, and for its role as a cryoprotectant in the preservation of cell and microorganism. Despite its extensive use across various fields, its impact on plant pathogens has received comparatively less attention in existing literature. This study focuses on investigating the effects of DMSO on Fusarium graminearum, a fungal pathogen that affects grains, through both bioinformatic and biological experiments. Our findings demonstrate that, although DMSO induces mycotoxin production in F. graminearum in vitro, it significantly reduces production and maturation of perithecia and pigmentation. Additionally, DMSO supplementation inhibits mycelial growth and conidial germination, potentially contributing to reduced pathogenicity on wheat coleoptiles. These results highlight DMSO's potential influence on plant pathogenic fungi beyond F. graminearum and may provide valuable insights for future research.</p>","PeriodicalId":20173,"journal":{"name":"Plant Pathology Journal","volume":"41 5","pages":"595-606"},"PeriodicalIF":2.5000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dimethyl Sulfoxide Suppresses Fusarium graminearum Pathogenicity by Modulating Key Life Cycle Traits.\",\"authors\":\"Taiying Li, Seunghyun Lee, Taewon Choi, Yurim Lim, Tianling Ma, Jungkwan Lee\",\"doi\":\"10.5423/PPJ.OA.06.2025.0074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Dimethyl sulfoxide (DMSO) is widely recognized for its versatile solvent properties, and for its role as a cryoprotectant in the preservation of cell and microorganism. Despite its extensive use across various fields, its impact on plant pathogens has received comparatively less attention in existing literature. This study focuses on investigating the effects of DMSO on Fusarium graminearum, a fungal pathogen that affects grains, through both bioinformatic and biological experiments. Our findings demonstrate that, although DMSO induces mycotoxin production in F. graminearum in vitro, it significantly reduces production and maturation of perithecia and pigmentation. Additionally, DMSO supplementation inhibits mycelial growth and conidial germination, potentially contributing to reduced pathogenicity on wheat coleoptiles. These results highlight DMSO's potential influence on plant pathogenic fungi beyond F. graminearum and may provide valuable insights for future research.</p>\",\"PeriodicalId\":20173,\"journal\":{\"name\":\"Plant Pathology Journal\",\"volume\":\"41 5\",\"pages\":\"595-606\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plant Pathology Journal\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.5423/PPJ.OA.06.2025.0074\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plant Pathology Journal","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.5423/PPJ.OA.06.2025.0074","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
Dimethyl Sulfoxide Suppresses Fusarium graminearum Pathogenicity by Modulating Key Life Cycle Traits.
Dimethyl sulfoxide (DMSO) is widely recognized for its versatile solvent properties, and for its role as a cryoprotectant in the preservation of cell and microorganism. Despite its extensive use across various fields, its impact on plant pathogens has received comparatively less attention in existing literature. This study focuses on investigating the effects of DMSO on Fusarium graminearum, a fungal pathogen that affects grains, through both bioinformatic and biological experiments. Our findings demonstrate that, although DMSO induces mycotoxin production in F. graminearum in vitro, it significantly reduces production and maturation of perithecia and pigmentation. Additionally, DMSO supplementation inhibits mycelial growth and conidial germination, potentially contributing to reduced pathogenicity on wheat coleoptiles. These results highlight DMSO's potential influence on plant pathogenic fungi beyond F. graminearum and may provide valuable insights for future research.