[2111at]PSMA-5靶向α治疗的进展。

IF 5.9 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Tadashi Watabe, Sadahiro Naka, Yoshifumi Shirakami, Kazuko Kaneda, Masashi Murakami, Atsushi Toyoshima, Jens Cardinale, Frederik L Giesel
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引用次数: 0

摘要

砹(211At)是一种发射α的核素,半衰期为7.2小时,可以用30兆电子伏特的回旋加速器产生。近年来,世界范围内生产基地的数量不断增加,引起了人们对2111at的越来越多的关注。我们开发了一种新的211At标记的psma靶向药物([211At]PSMA-5)。在对其抗肿瘤疗效和安全性进行临床前评估后,我们在转移性去势抵抗性前列腺癌患者中启动了一项首次人体临床试验。迄今为止,共有9例患者使用了该药物,我们报道了复发性和转移性病变中[2111at]PSMA-5的高积累。尽管基于211At的靶向α疗法的社会实施还需要进一步的努力,包括建立供应链和积累额外的临床证据,但使用211At的psma靶向α疗法由于其基于回旋加速器的生产、可持续性和清洁衰变的特点,代表了一种很有前途的治疗方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development of PSMA-Targeted Alpha Therapy Using [211At]PSMA-5.

Astatine (211At) is an alpha-emitting nuclide with a 7.2-hour half-life that can be produced using a 30-MeV cyclotron. In recent years, the number of production sites worldwide has been increasing, attracting growing attention to 211At. We have developed a novel 211At-labeled PSMA-targeted agent ([211At]PSMA-5). After conducting preclinical evaluations of its antitumor efficacy and safety, we initiated a first-in-human, investigator-initiated clinical trial in patients with metastatic castration-resistant prostate cancer. To date, the drug has been administered to a total of nine patients, and we have reported high accumulation of [211At]PSMA-5 in recurrent and metastatic lesions. While further efforts are required for the social implementation of 211At-based targeted alpha therapy, including the establishment of a supply chain and the accumulation of additional clinical evidence, PSMA-targeted alpha therapy using 211At represents a promising treatment modality owing to its cyclotron-based production, sustainability, and clean decay characteristics.

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来源期刊
Seminars in nuclear medicine
Seminars in nuclear medicine 医学-核医学
CiteScore
9.80
自引率
6.10%
发文量
86
审稿时长
14 days
期刊介绍: Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.
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