Joviane Daher, Ziad Koberssy, Jared C Durieux, Ornina Atieh, Jhony Baissary, Marc Abboud, Grace A McComsey
{"title":"COVID感染后1年的认知功能。","authors":"Joviane Daher, Ziad Koberssy, Jared C Durieux, Ornina Atieh, Jhony Baissary, Marc Abboud, Grace A McComsey","doi":"10.1093/ofid/ofaf583","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>While emerging evidence suggests a potential link between COVID-19 and cognitive impairment, there is a lack of prospective longitudinal research that objectively assesses cognitive outcomes after SARS-CoV-2 infection. This study aims to evaluate changes in cognitive function following COVID-19 in a group of individuals with baseline pre-infectious cognitive assessments.</p><p><strong>Methods: </strong>In this cohort study, cognitive function was objectively measured using the computerized Cognivue Clarity® device. All participants who had available Cognivue® testing were followed with a second Cognivue® assessment ∼1 year later. Based on whether they contracted COVID-19 during this period, participants were categorized into 2 groups according to COVID status.</p><p><strong>Results: </strong>We enrolled 110 participants with a median age of 45 years, 35% females and 46% white; 55 (50%) participants experienced a documented COVID-19 infection during the follow-up period (COVID + group), and the rest remained free of COVID infection (COVID- group). COVID- and COVID + groups were balanced for demographics and duration of follow-up. In the COVID + group, only memory scores changed during follow-up (+3.9; <i>P</i> = .03). The COVID- group showed improvements in the overall Cognivue® score (+2; <i>P</i> = .03), as well as in visuospatial (+1.9; <i>P</i> = .04), executive function (+2.2; <i>P</i> = .02), and naming language (+2.2; <i>P</i> = .01) scores. No statistically significant differences were observed in the overall cognitive score or its subdomains between the 2 groups.</p><p><strong>Conclusions: </strong>In a 45-year-old average population, no decrease in cognitive function was observed 1 year after COVID-19 infection.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 10","pages":"ofaf583"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481156/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cognitive Function 1 Year After COVID Infection.\",\"authors\":\"Joviane Daher, Ziad Koberssy, Jared C Durieux, Ornina Atieh, Jhony Baissary, Marc Abboud, Grace A McComsey\",\"doi\":\"10.1093/ofid/ofaf583\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>While emerging evidence suggests a potential link between COVID-19 and cognitive impairment, there is a lack of prospective longitudinal research that objectively assesses cognitive outcomes after SARS-CoV-2 infection. This study aims to evaluate changes in cognitive function following COVID-19 in a group of individuals with baseline pre-infectious cognitive assessments.</p><p><strong>Methods: </strong>In this cohort study, cognitive function was objectively measured using the computerized Cognivue Clarity® device. All participants who had available Cognivue® testing were followed with a second Cognivue® assessment ∼1 year later. Based on whether they contracted COVID-19 during this period, participants were categorized into 2 groups according to COVID status.</p><p><strong>Results: </strong>We enrolled 110 participants with a median age of 45 years, 35% females and 46% white; 55 (50%) participants experienced a documented COVID-19 infection during the follow-up period (COVID + group), and the rest remained free of COVID infection (COVID- group). COVID- and COVID + groups were balanced for demographics and duration of follow-up. In the COVID + group, only memory scores changed during follow-up (+3.9; <i>P</i> = .03). The COVID- group showed improvements in the overall Cognivue® score (+2; <i>P</i> = .03), as well as in visuospatial (+1.9; <i>P</i> = .04), executive function (+2.2; <i>P</i> = .02), and naming language (+2.2; <i>P</i> = .01) scores. No statistically significant differences were observed in the overall cognitive score or its subdomains between the 2 groups.</p><p><strong>Conclusions: </strong>In a 45-year-old average population, no decrease in cognitive function was observed 1 year after COVID-19 infection.</p>\",\"PeriodicalId\":19517,\"journal\":{\"name\":\"Open Forum Infectious Diseases\",\"volume\":\"12 10\",\"pages\":\"ofaf583\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481156/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Forum Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ofid/ofaf583\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/10/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Forum Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ofid/ofaf583","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Background: While emerging evidence suggests a potential link between COVID-19 and cognitive impairment, there is a lack of prospective longitudinal research that objectively assesses cognitive outcomes after SARS-CoV-2 infection. This study aims to evaluate changes in cognitive function following COVID-19 in a group of individuals with baseline pre-infectious cognitive assessments.
Methods: In this cohort study, cognitive function was objectively measured using the computerized Cognivue Clarity® device. All participants who had available Cognivue® testing were followed with a second Cognivue® assessment ∼1 year later. Based on whether they contracted COVID-19 during this period, participants were categorized into 2 groups according to COVID status.
Results: We enrolled 110 participants with a median age of 45 years, 35% females and 46% white; 55 (50%) participants experienced a documented COVID-19 infection during the follow-up period (COVID + group), and the rest remained free of COVID infection (COVID- group). COVID- and COVID + groups were balanced for demographics and duration of follow-up. In the COVID + group, only memory scores changed during follow-up (+3.9; P = .03). The COVID- group showed improvements in the overall Cognivue® score (+2; P = .03), as well as in visuospatial (+1.9; P = .04), executive function (+2.2; P = .02), and naming language (+2.2; P = .01) scores. No statistically significant differences were observed in the overall cognitive score or its subdomains between the 2 groups.
Conclusions: In a 45-year-old average population, no decrease in cognitive function was observed 1 year after COVID-19 infection.
期刊介绍：
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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