Ying Tang, Dan Liu, Sijia Li, Linqing Zhu, Yu Zhu, Nini Shi, Yunhang Wang, Ying Zhu, Tian Gao, Yuxia Ma
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引用次数: 0
摘要
目的：非侵入性脑刺激已被证明有益于老年人的认知功能。然而，经颅交流电刺激（tACS）对老年人认知功能的影响在各研究中并不一致，而且tACS的证据也存在局限性。本研究旨在探讨tACS是否改善老年人和老年阿尔茨海默病（AD）患者的认知功能和不同的认知领域（如学习记忆和执行功能）。方法：系统检索截至2024年12月25日的7个数据库（PubMed、Web of Science、Embase、The Cochrane Library、Scopus、PsycINFO和CINAHL）。效应量用95%置信区间的标准化平均差（SMD）表示，采用随机效应模型。结果：纳入14项随机对照试验（RCTs），偏倚风险相对较低。结论：tACS干预可显著改善老年AD患者的即时记忆和延迟记忆。需要进一步的大规模随机对照试验来阐明tACS对各个认知领域的具体影响，并研究最佳刺激参数以指导临床实践。
Effects of transcranial alternating current stimulation on cognitive function in older adults: a systematic review and meta-analysis of randomized controlled trials.
Objective: Non-invasive brain stimulation has been shown to benefit cognitive function in older adults. However, the effects of transcranial alternating current stimulation (tACS) on cognitive function in older adults have not been consistent across studies and there are limitations in the evidence for tACS. This study aims to investigate whether tACS improves cognitive function and different cognitive domains (e.g. learning memory and executive function) in older adults and older adults with Alzheimer's disease (AD).
Methods: A systematic search was conducted in seven databases (PubMed, Web of Science, Embase, The Cochrane Library, Scopus, PsycINFO, and CINAHL) up to 25 December 2024. Effect sizes were expressed as standardized mean differences (SMD) with 95% confidence intervals, and a random-effects model was applied.
Results: Fourteen randomized controlled trials (RCTs) were included, with a relatively low risk of bias. tACS had a significant effect on immediate memory (SMD = 0.66, p<0.01) and delayed memory (SMD = 0.68, p<0.01), but no significant effect on associative memory (SMD =-0.25, p = 0.61). Subgroup analyses revealed that tACS intervention significantly improved immediate and delayed memory in older adults with AD, but had no significant effect on healthy older adults.
Conclusion: tACS intervention significantly improves immediate memory and delayed memory in older adults with AD. Further large-scale RCTs are needed to clarify the specific effects of tACS on various cognitive domains, and optimal stimulation parameters should be investigated to guide clinical practice.
期刊介绍：
Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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