免疫治疗时代的头颈部肿瘤手术:综述。

IF 5.6 1区 医学 Q1 OTORHINOLARYNGOLOGY
Nabil F Saba, Nader G Zalaquett, Saad Rashid, Karthik N Rao, Robert P Takes, Carol Bradford, Remco de Bree, Jonathan J Beitler, Arlene A Forastiere, Jan B Vermorken, Anthea L Hammond, Yong Teng, Nicole C Schmitt, Alfio Ferlito
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引用次数: 0

摘要

重要性:头颈部鳞状细胞癌(HNSCC)是一种具有挑战性的恶性疾病,具有显著的发病率和死亡率。救助性手术,除了其他可用的治疗方式,是局部复发性HNSCC的重要治疗干预措施,提供了改善局部控制和生存结果的潜力。然而,挽救性手术的指征仍然多样化且缺乏标准化,报道的5年生存率从10%到61%不等。近年来,将免疫治疗纳入复发性和局部晚期HNSCC的治疗已显示出良好的潜力。尽管术前免疫治疗已经改善了其他恶性肿瘤(如非小细胞肺癌)的预后,但将其纳入HNSCC手术方案,无论是原发性还是补救性,仍处于早期阶段。早期的单机构试验表明,对于复发性或持续性HNSCC患者,联合免疫治疗和挽救性手术可以提高生存率,降低复发率,并改善其他预后。观察:本综述通过评估目前的证据、临床意义和这种综合方法的未来方向,探讨了免疫治疗时代HNSCC抢救手术的发展前景。结论和相关性:免疫治疗的进展和未来临床试验的发展,将免疫治疗纳入HNSCC抢救环境,有可能加强患者选择和优化手术结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Head and Neck Cancer Salvage Surgery in the Era of Immunotherapy and Beyond: A Review.

Importance: Head and neck squamous cell carcinoma (HNSCC) is a challenging malignant condition associated with significant morbidity and mortality. Salvage surgery, in addition to other available treatment modalities, constitutes an important therapeutic intervention for locoregionally recurrent HNSCC, offering the potential for improved locoregional control and survival outcomes. However, the indications for salvage surgery remain diverse and poorly standardized, with reported 5-year survival outcome rates ranging from 10% to 61%. In recent years, the incorporation of immunotherapy into the management of recurrent and locally advanced HNSCC has shown promising potential. Although preoperative immunotherapy has resulted in improved outcomes in other malignant neoplasms, such as non-small cell lung cancer, its integration into HNSCC surgical protocols whether in the primary or salvage setting is still in its early stages. Early single-institution trials suggest combining immunotherapy with salvage surgery may enhance survival, reduce recurrence rates, and improve other outcomes for patients with recurrent or persistent HNSCC.

Observations: This review explores the evolving landscape of HNSCC salvage surgery in the era of immunotherapy by assessing current evidence, clinical implications, and future directions for this integrated approach.

Conclusions and relevance: Advances in immunotherapy and the development of future clinical trials incorporating immunotherapy in the HNSCC salvage setting have the potential to enhance patient selection and optimize surgical outcomes.

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来源期刊
CiteScore
9.10
自引率
5.10%
发文量
230
期刊介绍: JAMA Otolaryngology–Head & Neck Surgery is a globally recognized and peer-reviewed medical journal dedicated to providing up-to-date information on diseases affecting the head and neck. It originated in 1925 as Archives of Otolaryngology and currently serves as the official publication for the American Head and Neck Society. As part of the prestigious JAMA Network, a collection of reputable general medical and specialty publications, it ensures the highest standards of research and expertise. Physicians and scientists worldwide rely on JAMA Otolaryngology–Head & Neck Surgery for invaluable insights in this specialized field.
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