{"title":"中性粒细胞-淋巴细胞比值和血小板-淋巴细胞比值对急诊剖宫产术后手术部位感染的联合预测价值：一项回顾性病例对照研究。","authors":"Xuemei Yang, Weina Yang, Qianqian He, Xiuqing Zhou, Qianwen Liu, Haiying Li","doi":"10.3389/fsurg.2025.1670583","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) independently and in combination for surgical site infection (SSI) after emergency cesarean section (CS).</p><p><strong>Method: </strong>This retrospective case-control study was conducted at the Maternity Medical Centre in China, a large tertiary teaching medical centre, between January 2019 and February 2022. A total of 627 patients with emergency CS were enrolled, and cases (post-SSI) and controls (without post-SSI) were matched 1:2. Various demographic, clinical and obstetric characteristics were collected. Laboratory values were measured on preoperative and postoperative days 1, 3. Univariate and multivariate logistic regression analyses were conducted to identify the influencing factors. The predictive values of NLR and PLR independently and in combination for SSI were evaluated using receiver operating characteristics (ROC) analysis.</p><p><strong>Result: </strong>In the univariate analysis, the BMI before delivery, preoperative NLR and PLR, and postoperative day 1 NLR and PLR et al. were significantly different between the two groups (<i>P</i> < 0.05). In multivariate analysis, BMI before delivery > 28.89 kg/m<sup>2</sup>, preoperative NLR > 9.89 and PLR > 177.99 appeared to be independent predictors of SSI after emergency CS. Combined indices of BMI before delivery, NLR and PLR were significantly more predictive of SSI after emergency CS than independent indices (AUC 0.85, <i>P</i> < 0.001, 95% CI 0.757-0.912, sensitivity 79.1%, and specificity 88.5%).</p><p><strong>Conlusion: </strong>The combined index of BMI before delivery, preoperative NLR and PLR may be a simple, sensitive, inexpensive, versatile, and rapid test for predicting SSI after emergency CS. Of course, further prospective research and external verification will be more scientific and also our future work focus.</p>","PeriodicalId":12564,"journal":{"name":"Frontiers in Surgery","volume":"12 ","pages":"1670583"},"PeriodicalIF":1.6000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479398/pdf/","citationCount":"0","resultStr":"{\"title\":\"Combined predictive values of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for surgical site infection after emergency cesarean section: a retrospective case-control study.\",\"authors\":\"Xuemei Yang, Weina Yang, Qianqian He, Xiuqing Zhou, Qianwen Liu, Haiying Li\",\"doi\":\"10.3389/fsurg.2025.1670583\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) independently and in combination for surgical site infection (SSI) after emergency cesarean section (CS).</p><p><strong>Method: </strong>This retrospective case-control study was conducted at the Maternity Medical Centre in China, a large tertiary teaching medical centre, between January 2019 and February 2022. A total of 627 patients with emergency CS were enrolled, and cases (post-SSI) and controls (without post-SSI) were matched 1:2. Various demographic, clinical and obstetric characteristics were collected. Laboratory values were measured on preoperative and postoperative days 1, 3. Univariate and multivariate logistic regression analyses were conducted to identify the influencing factors. The predictive values of NLR and PLR independently and in combination for SSI were evaluated using receiver operating characteristics (ROC) analysis.</p><p><strong>Result: </strong>In the univariate analysis, the BMI before delivery, preoperative NLR and PLR, and postoperative day 1 NLR and PLR et al. were significantly different between the two groups (<i>P</i> < 0.05). In multivariate analysis, BMI before delivery > 28.89 kg/m<sup>2</sup>, preoperative NLR > 9.89 and PLR > 177.99 appeared to be independent predictors of SSI after emergency CS. Combined indices of BMI before delivery, NLR and PLR were significantly more predictive of SSI after emergency CS than independent indices (AUC 0.85, <i>P</i> < 0.001, 95% CI 0.757-0.912, sensitivity 79.1%, and specificity 88.5%).</p><p><strong>Conlusion: </strong>The combined index of BMI before delivery, preoperative NLR and PLR may be a simple, sensitive, inexpensive, versatile, and rapid test for predicting SSI after emergency CS. Of course, further prospective research and external verification will be more scientific and also our future work focus.</p>\",\"PeriodicalId\":12564,\"journal\":{\"name\":\"Frontiers in Surgery\",\"volume\":\"12 \",\"pages\":\"1670583\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479398/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fsurg.2025.1670583\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fsurg.2025.1670583","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
Combined predictive values of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for surgical site infection after emergency cesarean section: a retrospective case-control study.
Objective: This study aims to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) independently and in combination for surgical site infection (SSI) after emergency cesarean section (CS).
Method: This retrospective case-control study was conducted at the Maternity Medical Centre in China, a large tertiary teaching medical centre, between January 2019 and February 2022. A total of 627 patients with emergency CS were enrolled, and cases (post-SSI) and controls (without post-SSI) were matched 1:2. Various demographic, clinical and obstetric characteristics were collected. Laboratory values were measured on preoperative and postoperative days 1, 3. Univariate and multivariate logistic regression analyses were conducted to identify the influencing factors. The predictive values of NLR and PLR independently and in combination for SSI were evaluated using receiver operating characteristics (ROC) analysis.
Result: In the univariate analysis, the BMI before delivery, preoperative NLR and PLR, and postoperative day 1 NLR and PLR et al. were significantly different between the two groups (P < 0.05). In multivariate analysis, BMI before delivery > 28.89 kg/m2, preoperative NLR > 9.89 and PLR > 177.99 appeared to be independent predictors of SSI after emergency CS. Combined indices of BMI before delivery, NLR and PLR were significantly more predictive of SSI after emergency CS than independent indices (AUC 0.85, P < 0.001, 95% CI 0.757-0.912, sensitivity 79.1%, and specificity 88.5%).
Conlusion: The combined index of BMI before delivery, preoperative NLR and PLR may be a simple, sensitive, inexpensive, versatile, and rapid test for predicting SSI after emergency CS. Of course, further prospective research and external verification will be more scientific and also our future work focus.
期刊介绍：
Evidence of surgical interventions go back to prehistoric times. Since then, the field of surgery has developed into a complex array of specialties and procedures, particularly with the advent of microsurgery, lasers and minimally invasive techniques. The advanced skills now required from surgeons has led to ever increasing specialization, though these still share important fundamental principles.
Frontiers in Surgery is the umbrella journal representing the publication interests of all surgical specialties. It is divided into several “Specialty Sections” listed below. All these sections have their own Specialty Chief Editor, Editorial Board and homepage, but all articles carry the citation Frontiers in Surgery.
Frontiers in Surgery calls upon medical professionals and scientists from all surgical specialties to publish their experimental and clinical studies in this journal. By assembling all surgical specialties, which nonetheless retain their independence, under the common umbrella of Frontiers in Surgery, a powerful publication venue is created. Since there is often overlap and common ground between the different surgical specialties, assembly of all surgical disciplines into a single journal will foster a collaborative dialogue amongst the surgical community. This means that publications, which are also of interest to other surgical specialties, will reach a wider audience and have greater impact.
The aim of this multidisciplinary journal is to create a discussion and knowledge platform of advances and research findings in surgical practice today to continuously improve clinical management of patients and foster innovation in this field.
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