Ioannis Mavroudis, Foivos Petridis, Katerina Franekova, Malina Visternicu, Viorica Rarinca, Vasile Burlui, Alin Ciobica, Bogdan Novac, Irina Dobrin, Mihai Marian Hogas, Erica Bovari, Cristina Albert, Dimitrios Kazis
{"title":"功能性认知障碍:诊断的挑战,临床特征,和未来的方向在一个误解的条件。","authors":"Ioannis Mavroudis, Foivos Petridis, Katerina Franekova, Malina Visternicu, Viorica Rarinca, Vasile Burlui, Alin Ciobica, Bogdan Novac, Irina Dobrin, Mihai Marian Hogas, Erica Bovari, Cristina Albert, Dimitrios Kazis","doi":"10.3389/fnagi.2025.1665510","DOIUrl":null,"url":null,"abstract":"<p><p>Functional Cognitive Disorder (FCD), a condition marked by significant subjective cognitive complaints in the absence of identifiable neurological disease, is increasingly recognized as a distinct and underdiagnosed entity in clinical practice. This review synthesizes recent findings to clarify its diagnostic features, differentiate it from other cognitive syndromes such as mild cognitive impairment and dementia, and explore its psychological underpinnings. We examined longitudinal studies, meta-analyses, and clinical frameworks to identify patterns of symptom presentation, cognitive performance, and psychosocial factors. Findings reveal that FCD is characterized by inconsistent cognitive deficits, preserved functional independence, and heightened help-seeking behavior, often accompanied by anxiety, metacognitive dysfunction, and maladaptive beliefs about memory. Unlike neurodegenerative conditions, FCD follows a stable, non-progressive course and shows no evidence of conversion to dementia when accurately diagnosed. Enhanced clinical recognition and structured assessment approaches are crucial for improving diagnostic accuracy, minimizing patient distress, and avoiding unnecessary medical interventions. Further research is needed to standardize diagnostic criteria and develop targeted therapeutic strategies.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1665510"},"PeriodicalIF":4.5000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479420/pdf/","citationCount":"0","resultStr":"{\"title\":\"Functional Cognitive Disorder: diagnostic challenges, clinical features, and future directions in a misunderstood condition.\",\"authors\":\"Ioannis Mavroudis, Foivos Petridis, Katerina Franekova, Malina Visternicu, Viorica Rarinca, Vasile Burlui, Alin Ciobica, Bogdan Novac, Irina Dobrin, Mihai Marian Hogas, Erica Bovari, Cristina Albert, Dimitrios Kazis\",\"doi\":\"10.3389/fnagi.2025.1665510\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Functional Cognitive Disorder (FCD), a condition marked by significant subjective cognitive complaints in the absence of identifiable neurological disease, is increasingly recognized as a distinct and underdiagnosed entity in clinical practice. This review synthesizes recent findings to clarify its diagnostic features, differentiate it from other cognitive syndromes such as mild cognitive impairment and dementia, and explore its psychological underpinnings. We examined longitudinal studies, meta-analyses, and clinical frameworks to identify patterns of symptom presentation, cognitive performance, and psychosocial factors. Findings reveal that FCD is characterized by inconsistent cognitive deficits, preserved functional independence, and heightened help-seeking behavior, often accompanied by anxiety, metacognitive dysfunction, and maladaptive beliefs about memory. Unlike neurodegenerative conditions, FCD follows a stable, non-progressive course and shows no evidence of conversion to dementia when accurately diagnosed. Enhanced clinical recognition and structured assessment approaches are crucial for improving diagnostic accuracy, minimizing patient distress, and avoiding unnecessary medical interventions. 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Functional Cognitive Disorder: diagnostic challenges, clinical features, and future directions in a misunderstood condition.
Functional Cognitive Disorder (FCD), a condition marked by significant subjective cognitive complaints in the absence of identifiable neurological disease, is increasingly recognized as a distinct and underdiagnosed entity in clinical practice. This review synthesizes recent findings to clarify its diagnostic features, differentiate it from other cognitive syndromes such as mild cognitive impairment and dementia, and explore its psychological underpinnings. We examined longitudinal studies, meta-analyses, and clinical frameworks to identify patterns of symptom presentation, cognitive performance, and psychosocial factors. Findings reveal that FCD is characterized by inconsistent cognitive deficits, preserved functional independence, and heightened help-seeking behavior, often accompanied by anxiety, metacognitive dysfunction, and maladaptive beliefs about memory. Unlike neurodegenerative conditions, FCD follows a stable, non-progressive course and shows no evidence of conversion to dementia when accurately diagnosed. Enhanced clinical recognition and structured assessment approaches are crucial for improving diagnostic accuracy, minimizing patient distress, and avoiding unnecessary medical interventions. Further research is needed to standardize diagnostic criteria and develop targeted therapeutic strategies.
期刊介绍:
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.