Xiaoxing Lai, Hongwei Zhu, Yonghua Cai, Baoyu Chen, Yang Li, Hongdi Du, Liping Zhang, Wenwen Wang, Shuxian Li, Xiaopeng Huo
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The dual-task training group received an exercise-cognitive dual-task training program, while the health education group received information on CF, including its symptoms, risk factors, and non-pharmacological prevention and treatment strategies. The primary outcomes were frailty status, while the secondary outcomes included cognitive function, balance and gait function, walking ability, and dual-task cognitive load.</p><p><strong>Results: </strong>A total of 72 participants (35 males) were enrolled, including 36 individuals (mean age: 74.81 ± 8.23 years, 17 males, mean BMI: 21.38 ± 2.83 kg/m<sup>2</sup>) in the dual-task training group, and 36 individuals (mean age: 76.50 ± 7.75 years, 18 males, mean BMI: 22.18 ± 2.12 kg/m<sup>2</sup>) in the health education group. Participants (n = 72) were 75.66 ± 7.9 years old; 48.6% (35/72) were male and 51.4% (37/72) were female. Following the intervention, the dual-task training group exhibited significant improvements compared to the health education group in the Tilburg Frailty Index (5.14 ± 0.99 vs. 7.36 ± 1.07, <i>p</i> < 0.001) and Montreal Cognitive Assessment scores (27.25 ± 2.41 vs. 23.47 ± 1.87, <i>p</i> < 0.001). Additionally, the dual-task training group demonstrated superior outcomes in the Performance-Oriented Mobility Assessment (POMA) scores (24.64 ± 5.50 vs. 17.39 ± 4.38, <i>p</i> < 0.001), Time Up and Go Test (TUGT) indicators (10.66 ± 1.76 vs. 12.01 ± 2.21, <i>p</i> < 0.05), and cognitive load measures (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Exercise-cognitive dual-task training may effectively improve frailty status, cognitive function, physical performance, and dual-task cognitive load in older adults with CF, suggesting its potential for broader application in this population.</p><p><strong>Clinical trial registration: </strong>http://www.chictr.org.cn/, ChiCTR2400080105.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1639245"},"PeriodicalIF":4.5000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479488/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of exercise-cognitive dual-task training on cognitive frailty in older adults: a randomized controlled trial.\",\"authors\":\"Xiaoxing Lai, Hongwei Zhu, Yonghua Cai, Baoyu Chen, Yang Li, Hongdi Du, Liping Zhang, Wenwen Wang, Shuxian Li, Xiaopeng Huo\",\"doi\":\"10.3389/fnagi.2025.1639245\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to investigate the effects of exercise-cognitive dual-task training on frailty status, cognitive function, physical performance, and dual-task cognitive load in older adults with Cognitive frailty (CF) over a 16-week intervention period.</p><p><strong>Methods: </strong>This randomized controlled trial enrolled older adults with CF at community health service center in Chaoyang District, Beijing, between February and March 2024. 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Participants (n = 72) were 75.66 ± 7.9 years old; 48.6% (35/72) were male and 51.4% (37/72) were female. Following the intervention, the dual-task training group exhibited significant improvements compared to the health education group in the Tilburg Frailty Index (5.14 ± 0.99 vs. 7.36 ± 1.07, <i>p</i> < 0.001) and Montreal Cognitive Assessment scores (27.25 ± 2.41 vs. 23.47 ± 1.87, <i>p</i> < 0.001). 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引用次数: 0
摘要
目的：本研究旨在探讨运动-认知双任务训练对老年认知衰弱（CF）患者虚弱状态、认知功能、体能表现和双任务认知负荷的影响。方法：本随机对照试验于2024年2 - 3月在北京市朝阳区社区卫生服务中心招募CF老年患者。参与者按1:1的比例随机分配到双任务训练组或健康教育组。双任务训练组接受运动-认知双任务训练计划，而健康教育组接受CF的信息，包括其症状、危险因素和非药物预防和治疗策略。主要结果是虚弱状态，次要结果包括认知功能、平衡和步态功能、行走能力和双任务认知负荷。结果:共有72名参与者(35男性)登记,包括36人(平均年龄:74.81 ±8.23 年,17个男性,意味着身体质量指数:21.38 ±2.83 kg / m2)一心二用地培训组和36个人(平均年龄:76.50 ±7.75 年,18个男性,意味着身体质量指数:22.18 ±2.12 kg / m2)健康教育组。参与者（n = 72）年龄75.66 ± 7.9 ；男性占48.6%(35/72)，女性占51.4%（37/72）。干预后,一心二用地培训组相比表现出显著改善健康教育组在蒂尔堡脆弱指数(5.14 ±0.99 vs 7.36 ± 1.07,p p p p 结论:Exercise-cognitive一心二用地训练可以有效改善虚弱状态,认知功能,物理性能,并与CF一心二用地老年人认知负荷,建议其潜在的更广泛的应用在这个人口。临床试验注册：http://www.chictr.org.cn/, ChiCTR2400080105。
Effects of exercise-cognitive dual-task training on cognitive frailty in older adults: a randomized controlled trial.
Objective: This study aims to investigate the effects of exercise-cognitive dual-task training on frailty status, cognitive function, physical performance, and dual-task cognitive load in older adults with Cognitive frailty (CF) over a 16-week intervention period.
Methods: This randomized controlled trial enrolled older adults with CF at community health service center in Chaoyang District, Beijing, between February and March 2024. Participants were randomly assigned to either the dual-task training group or the health education group in a 1:1 ratio. The dual-task training group received an exercise-cognitive dual-task training program, while the health education group received information on CF, including its symptoms, risk factors, and non-pharmacological prevention and treatment strategies. The primary outcomes were frailty status, while the secondary outcomes included cognitive function, balance and gait function, walking ability, and dual-task cognitive load.
Results: A total of 72 participants (35 males) were enrolled, including 36 individuals (mean age: 74.81 ± 8.23 years, 17 males, mean BMI: 21.38 ± 2.83 kg/m2) in the dual-task training group, and 36 individuals (mean age: 76.50 ± 7.75 years, 18 males, mean BMI: 22.18 ± 2.12 kg/m2) in the health education group. Participants (n = 72) were 75.66 ± 7.9 years old; 48.6% (35/72) were male and 51.4% (37/72) were female. Following the intervention, the dual-task training group exhibited significant improvements compared to the health education group in the Tilburg Frailty Index (5.14 ± 0.99 vs. 7.36 ± 1.07, p < 0.001) and Montreal Cognitive Assessment scores (27.25 ± 2.41 vs. 23.47 ± 1.87, p < 0.001). Additionally, the dual-task training group demonstrated superior outcomes in the Performance-Oriented Mobility Assessment (POMA) scores (24.64 ± 5.50 vs. 17.39 ± 4.38, p < 0.001), Time Up and Go Test (TUGT) indicators (10.66 ± 1.76 vs. 12.01 ± 2.21, p < 0.05), and cognitive load measures (all p < 0.05).
Conclusion: Exercise-cognitive dual-task training may effectively improve frailty status, cognitive function, physical performance, and dual-task cognitive load in older adults with CF, suggesting its potential for broader application in this population.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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