Jian Li, Fa Gao, Fang Cao, Shan Lv, Yulong Hou, Wei Guo, Chongheng Zhang, Aidong Liu
{"title":"估计脉搏波速度与心血管疾病结局和全因死亡的关系——系统回顾和荟萃分析","authors":"Jian Li, Fa Gao, Fang Cao, Shan Lv, Yulong Hou, Wei Guo, Chongheng Zhang, Aidong Liu","doi":"10.3389/fcvm.2025.1641697","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><b>:</b> The estimated pulse wave velocity (ePWV), derived from age and mean blood pressure (MBP) in accordance with the Reference Values of Arterial Stiffness Collaboration, has emerged as a novel alternative indicator for assessing arterial stiffness. This systematic review and meta-analysis aims to assess the correlation of ePWV with the likelihood of adverse cardiovascular (CV) events and all-cause mortality.</p><p><strong>Methods: </strong>Studies published before February 2024 from PubMed, Embase, Cochrane Library, and Web of Science were searched. To ensure the completeness and timeliness of the included literature, a thorough re-search and update of the relevant literature were conducted on April 28, 2025. The data analysis was carried out utilizing STATA (V15.0).</p><p><strong>Results: </strong>A systematic review and meta-analysis of 20 studies involving 381,303 participants demonstrated that individuals with higher ePWV had significantly increased risks of total CV events (HR = 2.14, 95%CI: 1.70-2.71), CV mortality (HR = 3.64, 95%CI: 2.83-4.68), and all-cause mortality (HR = 1.85, 95%CI: 1.38-2.47). Specifically, for each 1 m/s increase in ePWV, the risks of these outcomes increased by 36%, 41%, and 37%, respectively. Analyses of population types further verified that elevated ePWV was independently associated with increased risks for all outcomes. For total CV events, the HRs were 1.79 (95%CI: 1.45-2.21) in the general population and 3.43 (95%CI: 2.62-4.49) in those with CVD. For CV mortality, the HRs were 4.90 (95%CI: 2.78-8.64) and 3.39 (95%CI: 2.56-4.49), respectively. For all-cause mortality, HRs were 2.28 (95%CI: 1.00-5.21) in the general population and 1.84 (95%CI: 1.20-1.42) in the CVD group. Moreover, each 1 m/s increase in ePWV was associated with a 27% and 54% increase in total CV event risk, a 28% and 54% increase in CV mortality, and a 47% and 30% increase in all-cause mortality in the general and CV populations, respectively.</p><p><strong>Conclusion: </strong>These findings highlight ePWV as a potential predictor of adverse health outcomes, warranting further research to establish reference values and compare with carotid-femoral pulse wave velocity.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024536235.</p>","PeriodicalId":12414,"journal":{"name":"Frontiers in Cardiovascular Medicine","volume":"12 ","pages":"1641697"},"PeriodicalIF":2.8000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479400/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of estimated pulse wave velocity with cardiovascular disease outcomes and all-cause death-a systematic review and meta-analysis.\",\"authors\":\"Jian Li, Fa Gao, Fang Cao, Shan Lv, Yulong Hou, Wei Guo, Chongheng Zhang, Aidong Liu\",\"doi\":\"10.3389/fcvm.2025.1641697\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong><b>:</b> The estimated pulse wave velocity (ePWV), derived from age and mean blood pressure (MBP) in accordance with the Reference Values of Arterial Stiffness Collaboration, has emerged as a novel alternative indicator for assessing arterial stiffness. This systematic review and meta-analysis aims to assess the correlation of ePWV with the likelihood of adverse cardiovascular (CV) events and all-cause mortality.</p><p><strong>Methods: </strong>Studies published before February 2024 from PubMed, Embase, Cochrane Library, and Web of Science were searched. To ensure the completeness and timeliness of the included literature, a thorough re-search and update of the relevant literature were conducted on April 28, 2025. The data analysis was carried out utilizing STATA (V15.0).</p><p><strong>Results: </strong>A systematic review and meta-analysis of 20 studies involving 381,303 participants demonstrated that individuals with higher ePWV had significantly increased risks of total CV events (HR = 2.14, 95%CI: 1.70-2.71), CV mortality (HR = 3.64, 95%CI: 2.83-4.68), and all-cause mortality (HR = 1.85, 95%CI: 1.38-2.47). Specifically, for each 1 m/s increase in ePWV, the risks of these outcomes increased by 36%, 41%, and 37%, respectively. Analyses of population types further verified that elevated ePWV was independently associated with increased risks for all outcomes. For total CV events, the HRs were 1.79 (95%CI: 1.45-2.21) in the general population and 3.43 (95%CI: 2.62-4.49) in those with CVD. For CV mortality, the HRs were 4.90 (95%CI: 2.78-8.64) and 3.39 (95%CI: 2.56-4.49), respectively. For all-cause mortality, HRs were 2.28 (95%CI: 1.00-5.21) in the general population and 1.84 (95%CI: 1.20-1.42) in the CVD group. 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Association of estimated pulse wave velocity with cardiovascular disease outcomes and all-cause death-a systematic review and meta-analysis.
Background: : The estimated pulse wave velocity (ePWV), derived from age and mean blood pressure (MBP) in accordance with the Reference Values of Arterial Stiffness Collaboration, has emerged as a novel alternative indicator for assessing arterial stiffness. This systematic review and meta-analysis aims to assess the correlation of ePWV with the likelihood of adverse cardiovascular (CV) events and all-cause mortality.
Methods: Studies published before February 2024 from PubMed, Embase, Cochrane Library, and Web of Science were searched. To ensure the completeness and timeliness of the included literature, a thorough re-search and update of the relevant literature were conducted on April 28, 2025. The data analysis was carried out utilizing STATA (V15.0).
Results: A systematic review and meta-analysis of 20 studies involving 381,303 participants demonstrated that individuals with higher ePWV had significantly increased risks of total CV events (HR = 2.14, 95%CI: 1.70-2.71), CV mortality (HR = 3.64, 95%CI: 2.83-4.68), and all-cause mortality (HR = 1.85, 95%CI: 1.38-2.47). Specifically, for each 1 m/s increase in ePWV, the risks of these outcomes increased by 36%, 41%, and 37%, respectively. Analyses of population types further verified that elevated ePWV was independently associated with increased risks for all outcomes. For total CV events, the HRs were 1.79 (95%CI: 1.45-2.21) in the general population and 3.43 (95%CI: 2.62-4.49) in those with CVD. For CV mortality, the HRs were 4.90 (95%CI: 2.78-8.64) and 3.39 (95%CI: 2.56-4.49), respectively. For all-cause mortality, HRs were 2.28 (95%CI: 1.00-5.21) in the general population and 1.84 (95%CI: 1.20-1.42) in the CVD group. Moreover, each 1 m/s increase in ePWV was associated with a 27% and 54% increase in total CV event risk, a 28% and 54% increase in CV mortality, and a 47% and 30% increase in all-cause mortality in the general and CV populations, respectively.
Conclusion: These findings highlight ePWV as a potential predictor of adverse health outcomes, warranting further research to establish reference values and compare with carotid-femoral pulse wave velocity.
期刊介绍：
Frontiers? Which frontiers? Where exactly are the frontiers of cardiovascular medicine? And who should be defining these frontiers?
At Frontiers in Cardiovascular Medicine we believe it is worth being curious to foresee and explore beyond the current frontiers. In other words, we would like, through the articles published by our community journal Frontiers in Cardiovascular Medicine, to anticipate the future of cardiovascular medicine, and thus better prevent cardiovascular disorders and improve therapeutic options and outcomes of our patients.
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