Xue Li, Ying Zhang, Jihui Li, Tong Zhao, YuChen Fan, Shuai Gao, Kai Wang
{"title":"成纤维细胞生长因子21 （FGF21）启动子甲基化在慢性乙型肝炎修复和再生中的价值。","authors":"Xue Li, Ying Zhang, Jihui Li, Tong Zhao, YuChen Fan, Shuai Gao, Kai Wang","doi":"10.3389/fcell.2025.1643250","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus (HBV) infection continues to pose a significant threat to global public health. The capacity for liver repair and regeneration plays a critical role in maintaining liver homeostasis during HBV infection. This study investigates the impact of FGF21 promoter methylation on liver repair and regeneration in chronic HBV infection.</p><p><strong>Methods: </strong>A total of 216 patients with chronic hepatitis B admitted to the Department of Hepatology, Qilu Hospital, Shandong University from October 2023 to October 2024, along with 15 healthy controls, were included in this study. FGF21 promoter methylation levels in peripheral blood mononuclear cells (PBMCs) were assessed using Methlight. Group comparisons were conducted using the Kruskal-Wallis Test, while Spearman correlation analysis was employed to examine the relationship between FGF21 promoter methylation levels and liver injury, repair, and regeneration in chronic HBV patients.</p><p><strong>Results: </strong>The methylation level of the FGF21 promoter in HBeAg(+) CHB patients was significantly lower compared to HBeAg(-) CHB patients and healthy controls. Additionally, HBeAg(+) CHB patients exhibited significantly higher viral loads and more severe liver damage than HBeAg(-) CHB patients. Spearman correlation analysis revealed that the methylation level of the FGF21 promoter in CHB patients was positively correlated with liver repair and regeneration capacity.</p><p><strong>Conclusion: </strong>The methylation level of FGF21 serves as an important biomarker for evaluating liver repair and regeneration ability in patients with HBV. It is closely associated with the extent of liver injury and viral load.</p>","PeriodicalId":12448,"journal":{"name":"Frontiers in Cell and Developmental Biology","volume":"13 ","pages":"1643250"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479408/pdf/","citationCount":"0","resultStr":"{\"title\":\"The value of fibroblast growth factor 21 (FGF21) promoter methylation in the repair and regeneration during the course of chronic hepatitis B.\",\"authors\":\"Xue Li, Ying Zhang, Jihui Li, Tong Zhao, YuChen Fan, Shuai Gao, Kai Wang\",\"doi\":\"10.3389/fcell.2025.1643250\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Hepatitis B virus (HBV) infection continues to pose a significant threat to global public health. The capacity for liver repair and regeneration plays a critical role in maintaining liver homeostasis during HBV infection. This study investigates the impact of FGF21 promoter methylation on liver repair and regeneration in chronic HBV infection.</p><p><strong>Methods: </strong>A total of 216 patients with chronic hepatitis B admitted to the Department of Hepatology, Qilu Hospital, Shandong University from October 2023 to October 2024, along with 15 healthy controls, were included in this study. FGF21 promoter methylation levels in peripheral blood mononuclear cells (PBMCs) were assessed using Methlight. Group comparisons were conducted using the Kruskal-Wallis Test, while Spearman correlation analysis was employed to examine the relationship between FGF21 promoter methylation levels and liver injury, repair, and regeneration in chronic HBV patients.</p><p><strong>Results: </strong>The methylation level of the FGF21 promoter in HBeAg(+) CHB patients was significantly lower compared to HBeAg(-) CHB patients and healthy controls. Additionally, HBeAg(+) CHB patients exhibited significantly higher viral loads and more severe liver damage than HBeAg(-) CHB patients. Spearman correlation analysis revealed that the methylation level of the FGF21 promoter in CHB patients was positively correlated with liver repair and regeneration capacity.</p><p><strong>Conclusion: </strong>The methylation level of FGF21 serves as an important biomarker for evaluating liver repair and regeneration ability in patients with HBV. It is closely associated with the extent of liver injury and viral load.</p>\",\"PeriodicalId\":12448,\"journal\":{\"name\":\"Frontiers in Cell and Developmental Biology\",\"volume\":\"13 \",\"pages\":\"1643250\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479408/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Cell and Developmental Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.3389/fcell.2025.1643250\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cell and Developmental Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3389/fcell.2025.1643250","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
The value of fibroblast growth factor 21 (FGF21) promoter methylation in the repair and regeneration during the course of chronic hepatitis B.
Background: Hepatitis B virus (HBV) infection continues to pose a significant threat to global public health. The capacity for liver repair and regeneration plays a critical role in maintaining liver homeostasis during HBV infection. This study investigates the impact of FGF21 promoter methylation on liver repair and regeneration in chronic HBV infection.
Methods: A total of 216 patients with chronic hepatitis B admitted to the Department of Hepatology, Qilu Hospital, Shandong University from October 2023 to October 2024, along with 15 healthy controls, were included in this study. FGF21 promoter methylation levels in peripheral blood mononuclear cells (PBMCs) were assessed using Methlight. Group comparisons were conducted using the Kruskal-Wallis Test, while Spearman correlation analysis was employed to examine the relationship between FGF21 promoter methylation levels and liver injury, repair, and regeneration in chronic HBV patients.
Results: The methylation level of the FGF21 promoter in HBeAg(+) CHB patients was significantly lower compared to HBeAg(-) CHB patients and healthy controls. Additionally, HBeAg(+) CHB patients exhibited significantly higher viral loads and more severe liver damage than HBeAg(-) CHB patients. Spearman correlation analysis revealed that the methylation level of the FGF21 promoter in CHB patients was positively correlated with liver repair and regeneration capacity.
Conclusion: The methylation level of FGF21 serves as an important biomarker for evaluating liver repair and regeneration ability in patients with HBV. It is closely associated with the extent of liver injury and viral load.
期刊介绍：
Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board.
The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology.
With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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