Felix S Bott, Paul Theo Zebhauser, Vanessa D Hohn, Özgün Turgut, Elisabeth S May, Laura Tiemann, Cristina Gil Ávila, Henrik Heitmann, Moritz M Nickel, Melissa A Day, Divya B Adhia, Yoni K Ashar, Tor D Wager, Yelena Granovsky, David Yarnitsky, Mark P Jensen, Joachim Gross, Markus Ploner
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Variations and ablations of model features yielded deeper insights into the relative importance of distinct electrophysiological brain features in assessing chronic pain.</p><p><strong>Interpretation: </strong>Our findings highlight challenges and provide guidance for developing EEG-based, scalable, and affordable biomarkers of chronic pain.</p><p><strong>Funding: </strong>This project was funded by the Deutsche Forschungsgemeinschaft and the Technical University of Munich.</p>","PeriodicalId":11494,"journal":{"name":"EBioMedicine","volume":"120 ","pages":"105955"},"PeriodicalIF":10.8000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring electroencephalographic chronic pain biomarkers: a mega-analysis.\",\"authors\":\"Felix S Bott, Paul Theo Zebhauser, Vanessa D Hohn, Özgün Turgut, Elisabeth S May, Laura Tiemann, Cristina Gil Ávila, Henrik Heitmann, Moritz M Nickel, Melissa A Day, Divya B Adhia, Yoni K Ashar, Tor D Wager, Yelena Granovsky, David Yarnitsky, Mark P Jensen, Joachim Gross, Markus Ploner\",\"doi\":\"10.1016/j.ebiom.2025.105955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic pain is associated with alterations in brain function, offering promising avenues for advancing diagnostic and therapeutic strategies. 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Exploring electroencephalographic chronic pain biomarkers: a mega-analysis.
Background: Chronic pain is associated with alterations in brain function, offering promising avenues for advancing diagnostic and therapeutic strategies. In particular, these alterations may serve as brain-based biomarkers to support diagnosis, guide treatment decisions and monitor clinical courses of chronic pain.
Methods: Motivated by this potential, this study analysed associations between chronic pain and changes of large-scale brain network function using resting-state electroencephalography (EEG) from 614 individuals with chronic pain, collected by research groups from Australia, Germany, Israel, New Zealand, and the US.
Findings: Employing a discovery-replication approach, we found limited replicability of associations between pain intensity and brain network connectivity. However, a mega-analysis combining all datasets revealed robust associations between pain intensity and large-scale brain network connectivity at theta frequencies and including the limbic network. Additionally, multivariate analyses identified connectivity patterns spanning theta, alpha, and beta frequencies with strong evidence for associations with pain intensity. Variations and ablations of model features yielded deeper insights into the relative importance of distinct electrophysiological brain features in assessing chronic pain.
Interpretation: Our findings highlight challenges and provide guidance for developing EEG-based, scalable, and affordable biomarkers of chronic pain.
Funding: This project was funded by the Deutsche Forschungsgemeinschaft and the Technical University of Munich.
EBioMedicineBiochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍：
eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.
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