芬芬烯酮:对心血管-肾-代谢综合征早期阶段有益的证据。

IF 2.9 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Diego Francisco Márquez, Alberto Ortiz, Daniel González-Moreno, Luis Miguel Ruilope, Gema Ruiz-Hurtado
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引用次数: 0

摘要

背景:心血管-肾代谢综合征(CKM)是最近提出的一个概念,它将慢性肾脏疾病(CKD)、心血管疾病(CVD)和代谢危险因素(如肥胖或糖尿病(DM))联系起来。摘要:非甾体矿物皮质激素受体拮抗剂芬尼酮已被证明可降低CKD和2型DM患者的心血管和肾脏预后。来自FIDELITY的数据,fideleo - dkd和FIGARO-DKD的汇总分析,显示CKD和2型DM患者的肾衰竭和心血管预后显著降低。此外,fineards - hf试验的数据显示,芬尼酮可预防蛋白尿型CKD患者的发病。关键信息:这些结果支持对CKM综合征进行早期干预的范式转变,目的是保护肾功能。Finerenone有望在更广泛的CKM框架内改变CKD的发展轨迹。正在进行的试验将进一步确定其在不同患者群体和CKM综合征阶段中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Finerenone: Evidence for benefit in Early Stages of Cardiovascular-Kidney-Metabolic Syndrome.

Background: Cardiovascular-kidney-metabolic (CKM) syndrome is a recently introduced concept that links chronic kidney disease (CKD), cardiovascular disease (CVD), and metabolic risk factors such as obesity or diabetes mellitus (DM). The use of eGFR <60 mL/min/1.73 m² as a CKD indicator often detects more advanced stages of renal disease, even though risk is present at earlier stages, particularly in the presence of albuminuria.

Summary: The non-steroidal mineralocorticoid receptor antagonist finerenone has demonstrated efficacy in reducing cardiovascular and renal outcomes in patients with CKD and type 2 DM. Data from FIDELITY, a pooled analysis of FIDELIO-DKD and FIGARO-DKD, showed significant reductions in kidney failure and cardiovascular outcomes in patients with CKD and type 2 DM. Moreover, data from FINEARTS-HF trial revealed that finerenone prevents onset of albuminuric CKD in patients.

Key messages: These results support a paradigm shift toward earlier intervention in CKM syndrome, with the aim of preserving renal function. Finerenone holds promise for changing the trajectory of CKD within a broader CKM framework. Ongoing trials will further define its role in diverse patient populations and stages of CKM syndrome.

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来源期刊
Cardiorenal Medicine
Cardiorenal Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-UROLOGY & NEPHROLOGY
CiteScore
5.40
自引率
2.60%
发文量
25
审稿时长
>12 weeks
期刊介绍: The journal ''Cardiorenal Medicine'' explores the mechanisms by which obesity and other metabolic abnormalities promote the pathogenesis and progression of heart and kidney disease (cardiorenal metabolic syndrome). It provides an interdisciplinary platform for the advancement of research and clinical practice, focussing on translational issues.
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