低剂量秋水仙碱治疗冠状动脉疾病。

IF 4.1 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Cleveland Clinic Journal of Medicine Pub Date : 2025-10-01 DOI:10.3949/ccjm.92a.25005

Abhayjit Singh, Vikas Sunder, Leslie Cho

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引用次数: 0

摘要

心血管疾病仍然是全世界发病率和死亡率的主要原因。尽管炎症在动脉粥样硬化中起着重要作用，但直接针对炎症途径的治疗在改善临床结果方面的结果好坏参半。低剂量秋水仙碱最近被研究用于动脉粥样硬化性心血管疾病的治疗。我们探讨了秋水仙碱作为抗炎药的历史，回顾了秋水仙碱治疗动脉粥样硬化性心血管疾病的临床试验数据，并讨论了在这种情况下添加低剂量秋水仙碱的实际考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Low-dose colchicine for management of coronary artery disease.

Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Though inflammation plays an important role in atherogenesis, treatments directly targeting inflammatory pathways have had mixed results on improving clinical outcomes. Low-dose colchicine has been studied recently for the management of atherosclerotic cardiovascular disease. We explore the history of colchicine as an anti-inflammatory agent, review clinical trial data of colchicine for atherosclerotic cardiovascular disease, and discuss practical considerations for adding low-dose colchicine in this setting.

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来源期刊

Cleveland Clinic Journal of Medicine 医学-医学：内科

CiteScore

3.80

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The mission of Cleveland Clinic Journal of Medicine (CCJM) is to provide its readers with up-to-date, practical, clinical information relevant to internal medicine, cardiology, and related fields. Consistent with this mission, CCJM focuses on timely review articles and other content that has a continuing-education orientation rather than on original research or case reports. CCJM authors, drawn from Cleveland Clinic and other top medical institutions throughout the world, are asked to identify new findings that are changing the practice of medicine and to advise readers how to apply them in daily patient care. Authors are chosen for their experience, acquired through caring for patients, teaching other physicians, and researching clinical questions.