Mohammad Mohammadifard, Kowsar Ali Akbari, Pooyan Ahanrobai, Aminolah Vasigh
{"title":"静脉注射利多卡因对急诊腹腔镜胆囊切除术后气道并发症和血流动力学稳定性的影响：不同年龄组的随机对照试验","authors":"Mohammad Mohammadifard, Kowsar Ali Akbari, Pooyan Ahanrobai, Aminolah Vasigh","doi":"10.30476/beat.2025.106751.1604","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>This randomized controlled trial aimed to evaluate the effect of pre-extubation intravenous lidocaine (1 mg/Kg) on the incidence of airway complications and hemodynamic stability in patients undergoing emergency laparoscopic cholecystectomy, while accounting for age differences.</p><p><strong>Methods: </strong>The study was a prospective, single-center, randomized controlled trial conducted from 2021 to 2023 at Imam Khomeini Hospital, Ilam, Iran. Ninety patients undergoing emergency laparoscopic cholecystectomy were classified into two age groups (<50 and ≥50 years) and randomly assigned to receive either intravenous lidocaine (1 mg/Kg) or a standard extubation protocol. The primary outcomes included post-extubation airway complications, such as laryngospasm, cough, and sore throat, and the secondary outcomes included hemodynamic and respiratory parameters.</p><p><strong>Results: </strong>Lidocaine produced hemodynamic effects that differed by age group. In patients <50 years, systolic blood pressure (SBP) increased from 129.2±16.4 mmHg to 133.1±23.1 mmHg, while diastolic blood pressure (DBP) rose from 83.9±14.4 mmHg to 92.3±19.4 mmHg (both <i>p</i><0.001). Conversely, in patients ≥50 years old, SBP decreased from 160.5±26.7 mmHg to 145.2±19.7 mmHg, and DBP decreased from 107.9±19.5 mmHg to 99.0±16.1 mmHg (both <i>p</i><0.001). Airway complications exhibited non-significant tendencies, with a decreased incidence of cough in the older age group (15.6% vs. 31.8%) and an absence of laryngospasm in this age group. There were no serious adverse events (e.g., bronchospasm, arrhythmias).</p><p><strong>Conclusion: </strong>Intravenous lidocaine was safe and demonstrated a trend toward reducing airway complications at extubation in patients undergoing emergency laparoscopic cholecystectomy, particularly in elderly patients. However, this trend did not reach statistical significance, most likely due to insufficient statistical power.</p>","PeriodicalId":9333,"journal":{"name":"Bulletin of emergency and trauma","volume":"13 3","pages":"140-146"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482865/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of Intravenous Lidocaine on Airway Complications and Hemodynamic Stability Following Emergency Laparoscopic Cholecystectomy: A Randomized Controlled Trial in Different Age Groups.\",\"authors\":\"Mohammad Mohammadifard, Kowsar Ali Akbari, Pooyan Ahanrobai, Aminolah Vasigh\",\"doi\":\"10.30476/beat.2025.106751.1604\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>This randomized controlled trial aimed to evaluate the effect of pre-extubation intravenous lidocaine (1 mg/Kg) on the incidence of airway complications and hemodynamic stability in patients undergoing emergency laparoscopic cholecystectomy, while accounting for age differences.</p><p><strong>Methods: </strong>The study was a prospective, single-center, randomized controlled trial conducted from 2021 to 2023 at Imam Khomeini Hospital, Ilam, Iran. Ninety patients undergoing emergency laparoscopic cholecystectomy were classified into two age groups (<50 and ≥50 years) and randomly assigned to receive either intravenous lidocaine (1 mg/Kg) or a standard extubation protocol. The primary outcomes included post-extubation airway complications, such as laryngospasm, cough, and sore throat, and the secondary outcomes included hemodynamic and respiratory parameters.</p><p><strong>Results: </strong>Lidocaine produced hemodynamic effects that differed by age group. In patients <50 years, systolic blood pressure (SBP) increased from 129.2±16.4 mmHg to 133.1±23.1 mmHg, while diastolic blood pressure (DBP) rose from 83.9±14.4 mmHg to 92.3±19.4 mmHg (both <i>p</i><0.001). Conversely, in patients ≥50 years old, SBP decreased from 160.5±26.7 mmHg to 145.2±19.7 mmHg, and DBP decreased from 107.9±19.5 mmHg to 99.0±16.1 mmHg (both <i>p</i><0.001). Airway complications exhibited non-significant tendencies, with a decreased incidence of cough in the older age group (15.6% vs. 31.8%) and an absence of laryngospasm in this age group. There were no serious adverse events (e.g., bronchospasm, arrhythmias).</p><p><strong>Conclusion: </strong>Intravenous lidocaine was safe and demonstrated a trend toward reducing airway complications at extubation in patients undergoing emergency laparoscopic cholecystectomy, particularly in elderly patients. However, this trend did not reach statistical significance, most likely due to insufficient statistical power.</p>\",\"PeriodicalId\":9333,\"journal\":{\"name\":\"Bulletin of emergency and trauma\",\"volume\":\"13 3\",\"pages\":\"140-146\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482865/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of emergency and trauma\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30476/beat.2025.106751.1604\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of emergency and trauma","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30476/beat.2025.106751.1604","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of Intravenous Lidocaine on Airway Complications and Hemodynamic Stability Following Emergency Laparoscopic Cholecystectomy: A Randomized Controlled Trial in Different Age Groups.
Objectives: This randomized controlled trial aimed to evaluate the effect of pre-extubation intravenous lidocaine (1 mg/Kg) on the incidence of airway complications and hemodynamic stability in patients undergoing emergency laparoscopic cholecystectomy, while accounting for age differences.
Methods: The study was a prospective, single-center, randomized controlled trial conducted from 2021 to 2023 at Imam Khomeini Hospital, Ilam, Iran. Ninety patients undergoing emergency laparoscopic cholecystectomy were classified into two age groups (<50 and ≥50 years) and randomly assigned to receive either intravenous lidocaine (1 mg/Kg) or a standard extubation protocol. The primary outcomes included post-extubation airway complications, such as laryngospasm, cough, and sore throat, and the secondary outcomes included hemodynamic and respiratory parameters.
Results: Lidocaine produced hemodynamic effects that differed by age group. In patients <50 years, systolic blood pressure (SBP) increased from 129.2±16.4 mmHg to 133.1±23.1 mmHg, while diastolic blood pressure (DBP) rose from 83.9±14.4 mmHg to 92.3±19.4 mmHg (both p<0.001). Conversely, in patients ≥50 years old, SBP decreased from 160.5±26.7 mmHg to 145.2±19.7 mmHg, and DBP decreased from 107.9±19.5 mmHg to 99.0±16.1 mmHg (both p<0.001). Airway complications exhibited non-significant tendencies, with a decreased incidence of cough in the older age group (15.6% vs. 31.8%) and an absence of laryngospasm in this age group. There were no serious adverse events (e.g., bronchospasm, arrhythmias).
Conclusion: Intravenous lidocaine was safe and demonstrated a trend toward reducing airway complications at extubation in patients undergoing emergency laparoscopic cholecystectomy, particularly in elderly patients. However, this trend did not reach statistical significance, most likely due to insufficient statistical power.
期刊介绍：
BEAT: Bulletin of Emergency And Trauma is an international, peer-reviewed, quarterly journal coping with original research contributing to the field of emergency medicine and trauma. BEAT is the official journal of the Trauma Research Center (TRC) of Shiraz University of Medical Sciences (SUMS), Hungarian Trauma Society (HTS) and Lusitanian Association for Trauma and Emergency Surgery (ALTEC/LATES) aiming to be a publication of international repute that serves as a medium for dissemination and exchange of scientific knowledge in the emergency medicine and trauma. The aim of BEAT is to publish original research focusing on practicing and training of emergency medicine and trauma to publish peer-reviewed articles of current international interest in the form of original articles, brief communications, reviews, case reports, clinical images, and letters.
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