NAFLD患者AIP与T2DM发病的关系:一项回顾性研究

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Yan Chen, Qiufang Bai, Hao Hua
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引用次数: 0

摘要

背景与目的:本研究旨在探讨非酒精性脂肪性肝病(NAFLD)患者血浆粥样硬化指数(AIP)与2型糖尿病(T2DM)发生的关系。方法和结果:在这项回顾性研究中,根据AIP水平将2370例NAFLD患者分层。基线人口统计学、人体测量学和生化特征在各分位数之间进行比较。采用多变量logistic回归模型评估AIP与T2DM发病之间的关系,调整潜在混杂因素,包括年龄、性别、体重指数(BMI)、血红蛋白A1c (HbA1c)、吸烟状况、高血压(HBP)和肝酶。限制性三次样条(RCS)评估了剂量-反应关系,受试者工作特征(ROC)曲线比较了AIP对个体参数的预测性能。在完全调整模型(模型3)中,最高分位数(Q3)显示T2DM风险比Q1增加1.99倍(OR = 1.99, 95% CI: 1.29-3.08, P = 0.002)。观察到线性剂量-反应关系(非线性P = 0.663), AiP每增加1个单位对应的T2DM风险增加2.76倍(OR = 2.76, 95% CI: 1.54 ~ 4.93, P 0.05)。结论:AIP升高与NAFLD患者发生T2DM的风险增加独立相关,突出了其作为这一高危人群糖尿病预测生物标志物的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between AIP and incident T2DM in patients with NAFLD: a retrospective study.

Background and aim: This study aimed to investigate the relationship between atherogenic index of plasma (AIP) and incident type 2 diabetes mellitus (T2DM) in non-alcoholic fatty liver disease (NAFLD) patients.

Methods and results: In this retrospective study, 2,370 NAFLD patients were stratified into tertiles based on AIP levels. Baseline demographic, anthropometric, and biochemical characteristics were compared across tertiles. Multivariable logistic regression models were employed to assess the association between AIP and incident T2DM, adjusting for potential confounders, including age, sex, body mass index (BMI), hemoglobin A1c (HbA1c), smoking status, high blood pressure (HBP), and liver enzymes. Restricted cubic splines (RCS) evaluated dose-response relationships, and receiver operating characteristic (ROC) curves compared the predictive performance of AIP against individual parameters. In the fully adjusted model (Model 3), the highest tertile (Q3) demonstrated a 1.99-fold increased T2DM risk (OR = 1.99, 95% CI: 1.29-3.08, P = 0.002) versus Q1. A linear dose-response relationship was observed (P for non-linearity = 0.663), with each 1-unit AiP increase corresponding to a 2.76-fold higher T2DM risk (OR = 2.76, 95% CI: 1.54-4.93, P < 0.001). AIP demonstrated superior predictive performance for incident T2DM compared to traditional markers, as evidenced by higher area under the receiver operating characteristic curve (AUC) values. The relationship between AIP and incident T2DM remained consistent across various population subgroups (all interaction P-values>0.05).

Conclusions: Elevated AIP is independently associated with an increased risk of incident T2DM in NAFLD patients, highlighting its potential as a predictive biomarker for diabetes in this high-risk population.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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