年轻瘦人TyG指数与MASLD的关系:一项回顾性研究。

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Wenjing Xiao, Xinghe Sun, Hui Lv, Xiaohui Liu, Jihong Zhu
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引用次数: 0

摘要

背景:年轻瘦人群中TyG指数与MASLD之间的关系尚不清楚。方法:在这项回顾性研究中,我们分析了2019年1月至2023年12月在医疗管理中心接受腹部超声检查的18至35岁个体的数据。首先,我们将TyG指数分为四分位数,并使用逻辑回归模型来检验MASLD与TyG之间的关系。接下来,我们应用限制三次样条(RCS)来评估TyG和MASLD之间的关系是否遵循非线性模式。此外,我们按性别对分析进行分层,以探讨MASLD和TyG之间的关联在男性和女性之间是否存在差异。结果:共纳入20242例受试者,其中女性14763例(72.9%),年龄29.07岁(3.60岁)。MASLD的总发病率为5.1%。中位(IQR) TyG指数为8.0(7.6,8.2)。TyG指数与MASLD发病率呈倒l型关系,截断值为8.3。TyG指数每增加1个单位,其相关性在8.3以下(HR = 2.1; 95%CI: 1.4-3.4)和高于该阈值(HR = 12.1; 95%CI: 8.2-17.8)均具有显著性。性别与TyG指数之间存在显著的相互作用(P结论:在年轻人群中,较高的TyG指数与MASLD的风险增加相关,并且在性别之间观察到不同的模式。一旦TyG指数超过8.3,MASLD的风险就会急剧上升。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between TyG index and MASLD in lean young adults: a retrospective study.

Background: The relationship between the TyG index and MASLD in lean young populations remains unclear.

Methods: In this retrospective study, we analyzed data from individuals aged 18 to 35 Years old who underwent abdominal ultrasound examinations at a healthcare management center from January 2019 to December 2023. First, we categorized the TyG index into quartiles and used logistic regression models to examine the relationship between MASLD and TyG. Next, we applied restricted cubic splines (RCS) to assess whether the relationship between TyG and MASLD followed a nonlinear pattern. Additionally, we stratified the analysis by sex to explore whether the association between MASLD and TyG differed between males and females.

Results: A total of 20,242 participants (14763 women [72.9%]; [mean ± SD] age, 29.07 [3.60]) were included in the study. The overall incidence of MASLD was 5.1%. The median (IQR) TyG index was 8.0 (7.6, 8.2). The association between TyG index and the incidence of MASLD followed a reverse L-shaped, with a cut-off value of 8.3. For each 1-unit increase in the TyG index, the association was significant both below 8.3 (HR = 2.1; 95%CI: 1.4-3.4 ) and above this threshold (HR = 12.1; 95%CI: 8.2-17.8). A significant interaction between sex and the TyG index was observed (P < 0.001). Both males and females showing an increase in MASLD risk after the TyG index exceeded 8.3.

Conclusion: In young populations, higher TyG index is associated with an increased risk of MASLD, with distinct patterns observed between sexes. The risk of MASLD rises sharply once the TyG index exceeds 8.3.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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