芝麻素和α-亚麻酸对黑腹果蝇高脂血症致肥胖的保护作用。

IF 2.9 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
3 Biotech Pub Date : 2025-10-01 Epub Date: 2025-09-29 DOI:10.1007/s13205-025-04532-x
Abu Safana Biswas, Rajeshwari Selvaraj, Kamsagara Linganna Krishna, Ganavi Bethanagere Ramesha, Bharat Jayaprakash Byalahunashi, Seema Mehdi, Suman Pathak
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引用次数: 0

摘要

本研究在高脂肪饮食(HFD)诱导的黑腹果蝇肥胖模型中评估了植物成分,如芝麻素和α-亚麻酸(ALA)的抗高脂血症活性。雄性野生型果蝇喂食HFD(10%椰子油)诱导肥胖5天。肥胖果蝇用试验化合物(芝麻素,ALA)和瑞舒伐他汀作为标准药物治疗。芝麻素和ALA在急性毒性研究中进行了测试,以计算功效研究的剂量。体重、攀爬、负地向性和冷应激作为行为分析,脂质分析(总胆固醇、甘油三酯(TG、LDL和HDL))、葡萄糖水平和总蛋白含量作为生化分析。结果表明,芝麻素和ALA具有良好的效力,显著改善行为参数(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sesamin and α-linolenic acid protection against hyperlipidemia-induced obesity in Drosophila melanogaster model.

This study evaluates the anti-hyperlipidemic activity of phytoconstituents, such as sesamin and α-linolenic acid (ALA), in a high-fat diet (HFD)- induced Drosophila melanogaster obese model. Male wild-type Drosophila were fed an HFD (10% coconut oil) to induce obesity for 5 days. The obese flies were treated with the test compounds (sesamin, ALA) and rosuvastatin as a standard drug. Sesamin and ALA were tested for acute toxicity studies to calculate the doses for the efficacy study. Body weight, climbing, negative geotaxis, and cold stress were performed as behavioural assays, and lipid profiling (total cholesterol, triglycerides (TG, LDL, and HDL), glucose levels, and total protein content was determined as biochemical assays. Results demonstrated that sesamin and ALA have good potency in significantly improving behavioural parameters (P < 0.05). However, when compared, ALA showed better potency in enhancing these parameters. ALA has better potency in reducing TG and LDL levels, which are responsible for cardiovascular disease. Sesamin has better efficacy in improving the level of HDL, which an HFD reduces in flies, which is responsible for atherosclerosis. Sesamin reduced lipid profile in a dose-dependent manner, but required higher doses to achieve comparable lipid-lowering effects. In conclusion, ALA exhibited more substantial protective effects in reducing hyperlipidemia compared to control flies as an anti-hyperlipidemic agent in a dose-dependent manner.

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来源期刊
3 Biotech
3 Biotech Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
6.00
自引率
0.00%
发文量
314
期刊介绍: 3 Biotech publishes the results of the latest research related to the study and application of biotechnology to: - Medicine and Biomedical Sciences - Agriculture - The Environment The focus on these three technology sectors recognizes that complete Biotechnology applications often require a combination of techniques. 3 Biotech not only presents the latest developments in biotechnology but also addresses the problems and benefits of integrating a variety of techniques for a particular application. 3 Biotech will appeal to scientists and engineers in both academia and industry focused on the safe and efficient application of Biotechnology to Medicine, Agriculture and the Environment.
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