太空中的干细胞研究：在地球之外推进再生医学

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-10-02 DOI:10.1016/j.stem.2025.09.001

Maedeh Mozneb, Madelyn Arzt, Jemima Moses, Sean Escopete, Lauren Wiegand, Arun Sharma

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引用次数: 0

摘要

太空飞行提供了一个独特的环境，对干细胞生物学产生了深远的影响。在国际空间站（ISS）和模拟微重力环境下进行的实验揭示了干细胞增殖、分化和应激反应的变化，揭示了模拟太空飞行影响和利用微重力进行生物制造的可能性。在太空中飞行的干细胞衍生的类器官和组织模型对发育、疾病和衰老机制产生了深入的了解，而在太空生物制造方面的努力表明，干细胞的扩增和组织形成加速了潜在的转化和临床应用。最后，随着人类为长期的月球和火星任务做准备，天基干细胞研究提供了变革性的生物医学应用，但也提出了新的技术、监管、劳动力发展和伦理挑战。

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Stem cell research in space: Advancing regenerative medicine beyond Earth

Spaceflight provides a unique environment that profoundly influences stem cell biology. Experiments aboard the International Space Station (ISS) and in simulated microgravity have revealed altered stem cell proliferation, differentiation, and stress responses, unveiling possibilities for modeling impacts of spaceflight and harnessing microgravity for biomanufacturing. Stem cell-derived organoids and tissue models flown in space are yielding insights into development, disease, and aging mechanisms, while in-space biomanufacturing efforts demonstrate accelerated stem cell expansion and tissue formation for potential translational and clinical applications. Finally, as humanity prepares for long-duration lunar and Martian missions, space-based stem cell research offers transformative biomedical applications but also raises new technical, regulatory, workforce development, and ethical challenges.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.