用病人来源的类器官揭示癌症隐藏的神经通路

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-10-02 DOI:10.1016/j.stem.2025.08.008

Kevin M. Waters, Akil Merchant, De-Chen Lin

引用次数: 0

摘要

Chan等人1表明，肠道神经元影响胃癌类器官的脂质代谢，影响对关键酶的依赖性。利用CRISPR筛选和代谢分析，他们的工作强调了微环境信号如何影响胃癌的肿瘤代谢和潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Unmasking cancer’s hidden nerve route with patient-derived organoids

Chan et al.¹ show that enteric neurons influence lipid metabolism in gastric cancer organoids, affecting dependencies on key enzymes. Using CRISPR screening and metabolic analysis, their work highlights how microenvironmental signals impact tumor metabolism and potential treatment targets in gastric cancer.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.