利用7t MRI观察早期帕金森病的habenal和全脑功能连通性改变。

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-10-01 DOI:10.1038/s41531-025-00973-6

Bedia Samanci,Ulas Ay,Mark L Kuijf,Sonny Tan,Yasin Temel

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引用次数: 0

摘要

帕金森氏病（PD）传统上与基底神经节功能障碍有关，但证据强调更广泛的网络中断。Habenula参与调节情绪，奖励和运动功能，在PD中仍未得到充分研究。本研究利用7t MRI研究了早期PD患者的全脑和小脑功能连通性及其临床相关性。分析了104例早期PD患者和45例健康对照者的功能连通性。全脑分析显示PD患者的两个脑簇的连通性增加：第一个涉及中央旁小叶、额中回、眶额中回、中央前回、角回、中扣带回、辅助运动区；第二部分包括中扣带回和小脑小腿1。左缰与右侧中颞回和角回的连系增强（p-FDR = 0.011）。左旋多巴当量日剂量与中枢后回与小脑的连通性呈正相关（p-FDR = 0.020）。这些发现强调了早期运动和认知网络的中断，并表明这些区域可能是pd相关神经生物学变化的潜在标志。

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Altered habenular and whole brain functional connectivity in early Parkinson's disease using 7 T MRI.

Parkinson's disease (PD) is traditionally linked to basal ganglia dysfunction, yet evidence highlights broader network disruptions. Habenula, involved in regulating mood, reward, and motor functions, remains underexplored in PD. This study investigated whole-brain and habenular functional connectivity and their clinical correlates in early-stage PD using 7 T MRI. Functional connectivity was analyzed in 104 early-stage PD and 45 healthy controls. Whole-brain analysis revealed increased connectivity in two clusters in PD: the first involved paracentral lobule, middle frontal gyrus, orbital middle frontal gyrus, precentral gyrus, angular gyrus, middle cingulate gyrus, supplementary motor area; the second included middle cingulate gyrus and cerebellum Crus I. Left habenula showed increased connectivity with right middle temporal and angular gyri (p-FDR = 0.011). Levodopa equivalent daily dose positively correlated with connectivity between postcentral gyrus and cerebellum (p-FDR = 0.020). These findings highlight early motor and cognitive network disruptions and suggest these regions may serve as potential markers of PD-related neurobiological changes.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.