评估炎症性肠病患者快速眼动睡眠行为障碍的患病率和危险因素。

IF 8.2 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-10-01 DOI:10.1038/s41531-025-01051-7

Vijaya L Reddy,Zihan Chen,Sohail Dewain,Michelle Joo,Maya Bellomo,Erika Renkl,Sapna Patel,Emily Rivera,Laura Weisbein,Ahmed Ali,Michael D Kappelman,Brian B Koo

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引用次数: 0

摘要

快速眼动睡眠行为障碍（RBD）和炎症性肠病（IBD）与帕金森病相关。采用横断面设计，我们评估了IBD和对照组中RBD的患病率。共有158名对照组和462名IBD患者完成了IBD相关病史问卷、RBD单题筛查问卷（RBD1Q）和RBD筛查问卷。RBD患病率比较采用卡方检验。Logistic回归探讨了ibd相关因素与RBD （RBD1Q）的关系，调整了年龄、性别、种族和抗抑郁药的使用。IBD患者的RBD患病率较高（14.1%比5.1%,P = 0.002），这是由女性差异所致；13.3%的IBD和1.0%的对照组有RBD。在男性中，16.0%的IBD和11.9%的对照组患有RBD。IBD与bb0的三倍RBD相关（OR = 3.08, 95% CI [1.43, 6.62], P = 0.003）。合并RBD和IBD的男性IBD相关住院率高于不合并RBD的IBD男性（95.2% vs. 63.0%; P = 0.004）。RBD在IBD中比对照组更普遍，并且与严重IBD相关。

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Assessing prevalence and risk factors for REM sleep behavior disorder among patients with inflammatory bowel disease.

REM sleep behavior disorder (RBD) and inflammatory bowel disease (IBD) are associated with Parkinson's Disease. Using a cross-sectional design, we assessed RBD prevalence in IBD and controls. In total, 158 controls and 462 IBD patients completed IBD-related history questionnaires, the RBD Single-Question Screen (RBD1Q), and the RBD-Screening Questionnaire. RBD prevalence was compared using chi-squared testing. Logistic regression explored IBD-related factors associated with RBD (RBD1Q), adjusting for age, sex, race, and antidepressant usage. RBD prevalence was higher in IBD (14.1% vs. 5.1%; P = 0.002), driven by differences in women; 13.3% IBD and 1.0% controls had RBD. Among men, 16.0% IBD and 11.9% controls had RBD. IBD was associated with >threefold RBD odds (OR = 3.08, 95% CI [1.43, 6.62], P = 0.003). Men with RBD and IBD had higher IBD-related hospitalization rates than IBD males without RBD (95.2% vs. 63.0%; P = 0.004). RBD is more prevalent in IBD than in controls and is associated with severe IBD.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.