Rh（II）催化3-重氮唑啉和富电子芳基乙炔合成呋喃[2,3-b]吲哚

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-10-02 DOI:10.1039/d5cc04468e

Sandip Maiti, Charles Patriot Roy, Syed Ramizul Kabir, Jyotirmayee Dash

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引用次数: 0

摘要

我们报道了一种Rh（II）催化合成全芳香呋喃吲哚的方法，通过3-重氮唑吲哚与芳基乙炔的环丙烯化，然后原位重排。这种转变的一个独特方面是前所未有地激活了重氮唑吲哚部分的惰性C-2氧原子，提供了一种温和而有效的途径，从isatin到药学上相关的呋喃吲哚框架。

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Rh(II)-catalyzed synthesis of furo[2,3-b]indoles from 3-diazooxindoles and electron-rich arylacetylenes

We report a Rh(II)-catalyzed synthesis of fully aromatic furoindoles via cyclopropenation of 3-diazooxindoles with arylacetylenes, followed by in situ rearrangement. A unique aspect of this transformation is the unprecedented activation of the otherwise inert C-2 oxygen atom of the diazooxindole moiety, providing a mild and efficient route from isatins to pharmaceutically relevant furoindole frameworks.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.