Francesca Cannata, Viola Viola, Giulia Leanza, Alice Laudisio, Malak Faraj, Flavia Tramontana, Alessandra Piccoli, Rocky Strollo, Mauro Maccarrone, Fabrizio Russo, Gianluca Vadalà, Veronica Sansoni, Giovanni Lombardi, Giuseppe Banfi, Chiara Verdelli, Rocco Papalia, Nicola Napoli
{"title":"富含纤维的高碳水化合物（FEHC）饮食调节炎症而不影响老年肥胖妇女的骨骼健康：一项随机临床试验","authors":"Francesca Cannata, Viola Viola, Giulia Leanza, Alice Laudisio, Malak Faraj, Flavia Tramontana, Alessandra Piccoli, Rocky Strollo, Mauro Maccarrone, Fabrizio Russo, Gianluca Vadalà, Veronica Sansoni, Giovanni Lombardi, Giuseppe Banfi, Chiara Verdelli, Rocco Papalia, Nicola Napoli","doi":"10.1002/dmrr.70089","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>In older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p>To evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this clinical trial, 86 women aged 65–85 years with obesity (BMI ≥ 30 kg/m<sup>2</sup>) undergoing hip arthroplasty were assigned to a free control diet (FCD) or a FEHC diet (FEHC) group for 3 months before surgery. Clinical, systemic, and molecular assessments were performed, including gene expression analyses in bone and muscle tissues.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A significant reduction in waist circumference was observed over time in the FEHC group (<i>p</i> = 0.037), whereas no changes were detected in body weight, BMD or bone microarchitecture. Compared to FCD, the FEHC group showed reduced circulating IL-6 (<i>p</i> = 0.03), IL-8 (<i>p</i> = 0.022) and TNFα (<i>p</i> = 0.04) levels, along with lower IL-6 gene expression in muscle (<i>p</i> = 0.035). A strong trend of increased IGF-1 gene expression in muscle tissue of the FEHC group was also observed (<i>p</i> = 0.058). Gene expression analyses revealed a significant increase in WNT5a expression in muscle (<i>p</i> = 0.049), and an upward trend in WNT10b expression in bone (<i>p</i> = 0.055) while serum levels of DKK-1 were significantly higher in the FEHC group compared to FCD (<i>p</i> < 0.0001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The FEHC diet reduces systemic and local inflammation, without affecting skeletal health in older adults with obesity.</p>\n </section>\n </div>","PeriodicalId":11335,"journal":{"name":"Diabetes/Metabolism Research and Reviews","volume":"41 7","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483497/pdf/","citationCount":"0","resultStr":"{\"title\":\"Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial\",\"authors\":\"Francesca Cannata, Viola Viola, Giulia Leanza, Alice Laudisio, Malak Faraj, Flavia Tramontana, Alessandra Piccoli, Rocky Strollo, Mauro Maccarrone, Fabrizio Russo, Gianluca Vadalà, Veronica Sansoni, Giovanni Lombardi, Giuseppe Banfi, Chiara Verdelli, Rocco Papalia, Nicola Napoli\",\"doi\":\"10.1002/dmrr.70089\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>In older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>To evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this clinical trial, 86 women aged 65–85 years with obesity (BMI ≥ 30 kg/m<sup>2</sup>) undergoing hip arthroplasty were assigned to a free control diet (FCD) or a FEHC diet (FEHC) group for 3 months before surgery. Clinical, systemic, and molecular assessments were performed, including gene expression analyses in bone and muscle tissues.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>A significant reduction in waist circumference was observed over time in the FEHC group (<i>p</i> = 0.037), whereas no changes were detected in body weight, BMD or bone microarchitecture. Compared to FCD, the FEHC group showed reduced circulating IL-6 (<i>p</i> = 0.03), IL-8 (<i>p</i> = 0.022) and TNFα (<i>p</i> = 0.04) levels, along with lower IL-6 gene expression in muscle (<i>p</i> = 0.035). A strong trend of increased IGF-1 gene expression in muscle tissue of the FEHC group was also observed (<i>p</i> = 0.058). Gene expression analyses revealed a significant increase in WNT5a expression in muscle (<i>p</i> = 0.049), and an upward trend in WNT10b expression in bone (<i>p</i> = 0.055) while serum levels of DKK-1 were significantly higher in the FEHC group compared to FCD (<i>p</i> < 0.0001).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The FEHC diet reduces systemic and local inflammation, without affecting skeletal health in older adults with obesity.</p>\\n </section>\\n </div>\",\"PeriodicalId\":11335,\"journal\":{\"name\":\"Diabetes/Metabolism Research and Reviews\",\"volume\":\"41 7\",\"pages\":\"\"},\"PeriodicalIF\":6.0000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12483497/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes/Metabolism Research and Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/dmrr.70089\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes/Metabolism Research and Reviews","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/dmrr.70089","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Fibre-Enriched High-Carbohydrate (FEHC) Diet Modulates Inflammation Without Affecting Bone Health in Older Women With Obesity: A Randomised Clinical Trial
Background
In older adults, obesity is associated with frailty, conditions worsened by age related decline in bone mineral density (BMD) and muscle mass.
Objective
To evaluate whether a 3-month Fibre-Enriched High Carbohydrate (FEHC) diet preserves bone health, reduces inflammation and modulates Wnt signalling in older adults with obesity.
Methods
In this clinical trial, 86 women aged 65–85 years with obesity (BMI ≥ 30 kg/m2) undergoing hip arthroplasty were assigned to a free control diet (FCD) or a FEHC diet (FEHC) group for 3 months before surgery. Clinical, systemic, and molecular assessments were performed, including gene expression analyses in bone and muscle tissues.
Results
A significant reduction in waist circumference was observed over time in the FEHC group (p = 0.037), whereas no changes were detected in body weight, BMD or bone microarchitecture. Compared to FCD, the FEHC group showed reduced circulating IL-6 (p = 0.03), IL-8 (p = 0.022) and TNFα (p = 0.04) levels, along with lower IL-6 gene expression in muscle (p = 0.035). A strong trend of increased IGF-1 gene expression in muscle tissue of the FEHC group was also observed (p = 0.058). Gene expression analyses revealed a significant increase in WNT5a expression in muscle (p = 0.049), and an upward trend in WNT10b expression in bone (p = 0.055) while serum levels of DKK-1 were significantly higher in the FEHC group compared to FCD (p < 0.0001).
Conclusion
The FEHC diet reduces systemic and local inflammation, without affecting skeletal health in older adults with obesity.
期刊介绍：
Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.
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