{"title":"CO2激光治疗外阴硬化地衣二线的回顾性研究。","authors":"Gian Piero Siliquini, Margherita Giorgi, Concetta Strano, Francesca Accomasso, Beatrice Marina Pennati, Irene Fusco, Tiziano Zingoni, Fabrizio Bert, Valentina Elisabetta Bounous","doi":"10.1111/jog.70098","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Vulvar Lichen Sclerosus (VLS) represents a persistent inflammatory disease of the skin that particularly affects the genital area.</p>\n </section>\n \n <section>\n \n <h3> Aim</h3>\n \n <p>The study purpose was to investigate the effectiveness of CO<sub>2</sub> laser as a treatment of recalcitrant VLS. The parameters examined included treatment tolerance, patient satisfaction, symptoms, and VLS clinical markers.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This retrospective study enrolled 85 adult women affected by Vulvar Lichen Sclerosus (VLS), refractory to local corticosteroids. Patients were treated with three sessions of fractional CO<sub>2</sub> laser treatment at 4-week intervals. For vulvovaginal treatment, a device with a scanning handpiece and dedicated probes was used. The effectiveness of the treatment was evaluated at 1 month follow up (T1) and at 6 months follow up (T2) from the last treatment session. The Vulvar Health Index (VuHI) and the Vaginal Health Index score (VHI) were used. Patients assessed the severity of their symptoms (dyspareunia and dryness specifically) using the Visual Analogue Scale (VAS), a 10-point scale going from 0 (no symptoms) to 10 (maximum symptoms).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>VuHI showed significant improvement after completion of treatment compared to baseline (<i>p</i> < 0.001). VHI showed significant improvement after completion of treatment compared to baseline (<i>p</i> < 0.001). There was clear improvement, compared to baseline values, in the VAS score for superficial dyspareunia and for vulvar dryness.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Overall, the results of this study demonstrated that treatment of recalcitrant VLS with fractional CO<sub>2</sub> laser improved both clinical assessment and symptoms.</p>\n </section>\n </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484719/pdf/","citationCount":"0","resultStr":"{\"title\":\"Retrospective Study on CO2 Laser for Second-Line Treatment of Vulvar Lichen Sclerosus\",\"authors\":\"Gian Piero Siliquini, Margherita Giorgi, Concetta Strano, Francesca Accomasso, Beatrice Marina Pennati, Irene Fusco, Tiziano Zingoni, Fabrizio Bert, Valentina Elisabetta Bounous\",\"doi\":\"10.1111/jog.70098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Vulvar Lichen Sclerosus (VLS) represents a persistent inflammatory disease of the skin that particularly affects the genital area.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aim</h3>\\n \\n <p>The study purpose was to investigate the effectiveness of CO<sub>2</sub> laser as a treatment of recalcitrant VLS. The parameters examined included treatment tolerance, patient satisfaction, symptoms, and VLS clinical markers.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This retrospective study enrolled 85 adult women affected by Vulvar Lichen Sclerosus (VLS), refractory to local corticosteroids. Patients were treated with three sessions of fractional CO<sub>2</sub> laser treatment at 4-week intervals. For vulvovaginal treatment, a device with a scanning handpiece and dedicated probes was used. The effectiveness of the treatment was evaluated at 1 month follow up (T1) and at 6 months follow up (T2) from the last treatment session. The Vulvar Health Index (VuHI) and the Vaginal Health Index score (VHI) were used. Patients assessed the severity of their symptoms (dyspareunia and dryness specifically) using the Visual Analogue Scale (VAS), a 10-point scale going from 0 (no symptoms) to 10 (maximum symptoms).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>VuHI showed significant improvement after completion of treatment compared to baseline (<i>p</i> < 0.001). VHI showed significant improvement after completion of treatment compared to baseline (<i>p</i> < 0.001). There was clear improvement, compared to baseline values, in the VAS score for superficial dyspareunia and for vulvar dryness.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Overall, the results of this study demonstrated that treatment of recalcitrant VLS with fractional CO<sub>2</sub> laser improved both clinical assessment and symptoms.</p>\\n </section>\\n </div>\",\"PeriodicalId\":16593,\"journal\":{\"name\":\"Journal of Obstetrics and Gynaecology Research\",\"volume\":\"51 10\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484719/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Obstetrics and Gynaecology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70098\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Obstetrics and Gynaecology Research","FirstCategoryId":"3","ListUrlMain":"https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.70098","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Retrospective Study on CO2 Laser for Second-Line Treatment of Vulvar Lichen Sclerosus
Background
Vulvar Lichen Sclerosus (VLS) represents a persistent inflammatory disease of the skin that particularly affects the genital area.
Aim
The study purpose was to investigate the effectiveness of CO2 laser as a treatment of recalcitrant VLS. The parameters examined included treatment tolerance, patient satisfaction, symptoms, and VLS clinical markers.
Methods
This retrospective study enrolled 85 adult women affected by Vulvar Lichen Sclerosus (VLS), refractory to local corticosteroids. Patients were treated with three sessions of fractional CO2 laser treatment at 4-week intervals. For vulvovaginal treatment, a device with a scanning handpiece and dedicated probes was used. The effectiveness of the treatment was evaluated at 1 month follow up (T1) and at 6 months follow up (T2) from the last treatment session. The Vulvar Health Index (VuHI) and the Vaginal Health Index score (VHI) were used. Patients assessed the severity of their symptoms (dyspareunia and dryness specifically) using the Visual Analogue Scale (VAS), a 10-point scale going from 0 (no symptoms) to 10 (maximum symptoms).
Results
VuHI showed significant improvement after completion of treatment compared to baseline (p < 0.001). VHI showed significant improvement after completion of treatment compared to baseline (p < 0.001). There was clear improvement, compared to baseline values, in the VAS score for superficial dyspareunia and for vulvar dryness.
Conclusion
Overall, the results of this study demonstrated that treatment of recalcitrant VLS with fractional CO2 laser improved both clinical assessment and symptoms.
期刊介绍:
The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology.
The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.