{"title":"从柑橘皮中提取的植物化学物质抑制消化酶的潜力的研究:对生活方式疾病管理的序曲。","authors":"Lebohang Moloi, Sana Samson, Kadima Tshiyoyo, Kamogelo Maluleke, Marni Oberholzer, Itumeleng Baloyi, Samkelo Malgas","doi":"10.1080/14756366.2025.2564800","DOIUrl":null,"url":null,"abstract":"<p><p>The food industry relies on citrus fruits for juice, canned fruit, and jam, creating significant waste from peels, seeds, and pomace. This waste contains valuable phytochemicals like carotenoids, essential oils, (poly)phenols, pectin, and vitamins, which can be used as nutraceuticals or key ingredients in functional foods for managing diabetes and obesity. Repurposing citrus peel waste offers an excellent opportunity to advance biorefineries and the bioeconomy. Compounds derived from citrus have attracted attention for their potential therapeutic effects on diabetes and obesity, and their effectiveness depends on various mechanisms. This review summarises citrus-derived phytochemicals that inhibit α-glucosidase and pancreatic lipase <i>in vitro</i>, highlighting their potential as anti-diabetic and anti-obesity compounds. We also discuss progress in using molecular docking screening against key drug targets linked to type II diabetes and obesity. This review explores novel citrus phytochemicals for the development of nutraceuticals and functional food ingredients with enhanced health benefits.</p>","PeriodicalId":15769,"journal":{"name":"Journal of Enzyme Inhibition and Medicinal Chemistry","volume":"40 1","pages":"2564800"},"PeriodicalIF":5.4000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490385/pdf/","citationCount":"0","resultStr":"{\"title\":\"Investigation of the potential of phytochemicals derived from citrus peels to inhibit digestive enzymes: an overture to the management of lifestyle diseases.\",\"authors\":\"Lebohang Moloi, Sana Samson, Kadima Tshiyoyo, Kamogelo Maluleke, Marni Oberholzer, Itumeleng Baloyi, Samkelo Malgas\",\"doi\":\"10.1080/14756366.2025.2564800\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The food industry relies on citrus fruits for juice, canned fruit, and jam, creating significant waste from peels, seeds, and pomace. This waste contains valuable phytochemicals like carotenoids, essential oils, (poly)phenols, pectin, and vitamins, which can be used as nutraceuticals or key ingredients in functional foods for managing diabetes and obesity. Repurposing citrus peel waste offers an excellent opportunity to advance biorefineries and the bioeconomy. Compounds derived from citrus have attracted attention for their potential therapeutic effects on diabetes and obesity, and their effectiveness depends on various mechanisms. This review summarises citrus-derived phytochemicals that inhibit α-glucosidase and pancreatic lipase <i>in vitro</i>, highlighting their potential as anti-diabetic and anti-obesity compounds. We also discuss progress in using molecular docking screening against key drug targets linked to type II diabetes and obesity. This review explores novel citrus phytochemicals for the development of nutraceuticals and functional food ingredients with enhanced health benefits.</p>\",\"PeriodicalId\":15769,\"journal\":{\"name\":\"Journal of Enzyme Inhibition and Medicinal Chemistry\",\"volume\":\"40 1\",\"pages\":\"2564800\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490385/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Enzyme Inhibition and Medicinal Chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14756366.2025.2564800\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/10/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Enzyme Inhibition and Medicinal Chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14756366.2025.2564800","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/10/1 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Investigation of the potential of phytochemicals derived from citrus peels to inhibit digestive enzymes: an overture to the management of lifestyle diseases.
The food industry relies on citrus fruits for juice, canned fruit, and jam, creating significant waste from peels, seeds, and pomace. This waste contains valuable phytochemicals like carotenoids, essential oils, (poly)phenols, pectin, and vitamins, which can be used as nutraceuticals or key ingredients in functional foods for managing diabetes and obesity. Repurposing citrus peel waste offers an excellent opportunity to advance biorefineries and the bioeconomy. Compounds derived from citrus have attracted attention for their potential therapeutic effects on diabetes and obesity, and their effectiveness depends on various mechanisms. This review summarises citrus-derived phytochemicals that inhibit α-glucosidase and pancreatic lipase in vitro, highlighting their potential as anti-diabetic and anti-obesity compounds. We also discuss progress in using molecular docking screening against key drug targets linked to type II diabetes and obesity. This review explores novel citrus phytochemicals for the development of nutraceuticals and functional food ingredients with enhanced health benefits.
期刊介绍:
Journal of Enzyme Inhibition and Medicinal Chemistry publishes open access research on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents.
Journal of Enzyme Inhibition and Medicinal Chemistry aims to provide an international and interdisciplinary platform for the latest findings in enzyme inhibition research.
The journal’s focus includes current developments in:
Enzymology;
Cell biology;
Chemical biology;
Microbiology;
Physiology;
Pharmacology leading to drug design;
Molecular recognition processes;
Distribution and metabolism of biologically active compounds.