感知致残性身体疼痛和自杀意念的老年丙型肝炎病毒感染者治愈:法国多中心调查(ANRS CO13 HEPAVIH)。

IF 3.2 3区 医学 Q2 INFECTIOUS DISEASES
HIV Medicine Pub Date : 2025-10-01 DOI:10.1111/hiv.70121
Tangui Barré, Clémence Ramier, Camelia Protopopescu, Philippe Sogni, Karine Ory, Tounes Saidi, Sophie Abgrall, Sylvie Brégigeon-Ronot, Patrizia Carrieri, Fabienne Marcellin
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引用次数: 0

摘要

导读:自杀意念(SI)在HIV感染者(PWH)和慢性丙型肝炎病毒感染者(HCV)中非常普遍。长期HIV-HCV合并感染的个体面临特定的健康挑战,包括身体疼痛加剧。我们的目的是在控制了潜在的相关因素或混杂因素(如抑郁和精神活性物质使用)后,评估致残性身体疼痛是否与HCV治愈的老年PWH中的SI相关。方法:我们分析了参加法国ANRS CO13 HEPAVIH队列多中心横断面调查的hcv治愈PWH的数据。我们以SI(患者健康问卷-9的第九项得分为b>)为结果进行了多变量逻辑回归模型。使用WHOQOL-HIV BREF问卷第三项的答案≥“very much”来评估致残性身体疼痛。结果:研究人群包括396名hcv治愈的PWH(73.2%为男性),其中17.7%报告SI, 11.9%报告致残性身体疼痛。在调整抑郁(5.52[2.66-11.43])、物质使用和较低的社会关系相关生活质量(0.72[0.64-0.80])后,报告致残性身体疼痛的参与者发生SI的风险高出三倍(调整优势比[95%置信区间]:3.07[1.29-7.34])。结论:这些发现强调,鉴于其与SI的独立关联,应系统地解决PWH治愈的HCV致残性身体疼痛。常规艾滋病毒随访护理应结合疼痛、心理健康问题和缺乏社会支持的系统筛查。及时转诊到专门服务机构可能有助于预防这一人群未来的自杀行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Perceived disabling physical pain and suicidal ideation in aging people living with HIV cured of hepatitis C: A multi-center survey in France (ANRS CO13 HEPAVIH).

Introduction: Suicidal ideation (SI) is highly prevalent among people living with HIV (PWH) and those with chronic hepatitis C virus (HCV) infection. Individuals with long-term HIV-HCV co-infection face specific health challenges, including heightened physical pain. We aimed to assess whether disabling physical pain is associated with SI in aging PWH who have been cured of HCV, after controlling for potential correlates or confounders such as depression and psychoactive substance use.

Methods: We analysed data from HCV-cured PWH who participated in a multi-center cross-sectional survey embedded within the French ANRS CO13 HEPAVIH cohort. We performed a multivariable logistic regression model with SI (score >0 for the ninth item of the Patient Health Questionnaire-9) as the outcome. Disabling physical pain was assessed using an answer ≥'very much' to the third item from the WHOQOL-HIV BREF questionnaire.

Results: Study population comprised 396 HCV-cured PWH (73.2% male), among whom 17.7% reported SI and 11.9% reported disabling physical pain. Participants reporting disabling physical pain had a three-fold higher risk of SI (adjusted odds ratio [95% confidence interval]: 3.07 [1.29-7.34]), after adjustment for depression (5.52 [2.66-11.43]), substance use, and lower social relationships-related quality of life (0.72 [0.64-0.80]).

Conclusions: These findings highlight that disabling physical pain should be systematically addressed among PWH cured of HCV, given its independent association with SI. Routine HIV follow-up care should integrate systematic screening for pain, mental health problems, and lack of social support. Timely referral to specialized services may help prevent future suicidal behaviours in this population.

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来源期刊
HIV Medicine
HIV Medicine 医学-传染病学
CiteScore
5.10
自引率
10.00%
发文量
167
审稿时长
6-12 weeks
期刊介绍: HIV Medicine aims to provide an alternative outlet for publication of international research papers in the field of HIV Medicine, embracing clinical, pharmocological, epidemiological, ethical, preclinical and in vitro studies. In addition, the journal will commission reviews and other feature articles. It will focus on evidence-based medicine as the mainstay of successful management of HIV and AIDS. The journal is specifically aimed at researchers and clinicians with responsibility for treating HIV seropositive patients.
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