染色体外DNA在肿瘤发生和发展中的作用。

IF 3.5 3区医学 Q2 ONCOLOGY

Frontiers in Oncology Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI:10.3389/fonc.2025.1665024

Xiaoyang Ma, Xiaolin Yu, Chuan Wu, Lixing Song

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引用次数: 0

摘要

在肿瘤中，染色体外DNA （ecDNA）是癌基因表达、基因组不稳定、耐药性演变和患者预后不良的重要驱动因素。ecDNA存在于各种肿瘤中，但很少在正常细胞中发现。本文就ecDNA的结构、遗传学、发生、预后和功能等方面进行综述，为进一步开展ecDNA的研究提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of extrachromosomal DNA in tumorigenesis and progression.

In tumors, extrachromosomal DNA (ecDNA) is an important driver of oncogene expression, genomic instability, the evolution of drug resistance, and poor patient prognosis. ecDNA is present in various tumors but is rarely found in normal cells. Here, we provide a detailed review of the structure, genetics, occurrence, outcomes, and functions of ecDNA, offering further reference for research on ecDNA.

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来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.