妊娠早期非传统脂质参数与妊娠期糖尿病风险的关系

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Junmiao Xiang, Ruru Bao, Yundong Pan, Zhuhua Cai
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引用次数: 0

摘要

妊娠期糖尿病(GDM)是妊娠期常见的并发症,与母亲和婴儿的不良结局有关。非传统脂质参数水平升高与代谢紊乱有关。本研究探讨妊娠早期非传统脂质参数对24-28周GDM诊断的预测价值。方法:对2019年1月- 2023年8月温州医科大学附属第三医院1197例患者进行回顾性研究,采用logistic回归和分层分析方法,检验非传统血脂参数与GDM的相关性。采用曲线下面积法(AUC)评价脂质参数的诊断性能。Pearson相关分析明确了非传统脂质参数与新生儿出生体重的关系,以及它们与口服糖耐量试验(OGTT)血糖测量的关系。结果:在1197名参与者中,201人被诊断为GDM。GDM组非传统脂质参数水平显著升高。多变量分析确定了这些脂质指标,特别是非高密度脂蛋白c, AUC为64.0% (95% CI: 59.6%-68.4%),是所有模型中GDM的独立预测因子(P结论:妊娠早期非传统脂质参数是GDM的重要预测因子,特别是在考虑空腹血糖水平时。这些参数为早期诊断提供了潜在价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation between the first-trimester non-traditional lipid parameters with the risk of gestational diabetes mellitus in pregnancy.

Introduction: Gestational diabetes mellitus (GDM) is a common complication in pregnancy, linked to adverse outcomes for mothers and infants. Elevated levels of non-traditional lipid parameters have been associated with metabolic disorders. This study explores the predictive value of first-trimester non-traditional lipid parameters for GDM diagnosis at 24-28 weeks.

Methods: A retrospective study involving 1197 patients from The Third Affiliated Hospital of Wenzhou Medical University (January 2019 - August 2023) examined the correlation between non-traditional lipid parameters and GDM using logistic regression and stratified analyses. The diagnostic performance of the lipid parameters was evaluated using the area under the curve (AUC) method. Pearson correlation analysis clarified the relationship between non-traditional lipid parameters and neonatal birth weight, as well as their association with oral glucose tolerance test (OGTT) glycemic measures.

Results: Among 1197 participants, 201 were diagnosed with GDM. The GDM group exhibited significantly higher levels of non-traditional lipid parameters. Multivariate analysis identified these lipid measures, particularly Non-HDL-C with an AUC of 64.0% (95% CI: 59.6%-68.4%), as independent predictors of GDM across all models (P < 0.05), except for RC/HDL-C in model3. Most non-traditional lipid parameters demonstrated a linear relationship with GDM, with the exception of Non-HDL-C. Strong positive correlations were observed between fasting blood glucose levels and lipid ratios such as Non-HDL-C/HDL-C, LDL/HDL-C, TG/HDL-C, TC/HDL-C, and RC/HDL-C in patients with GDM. No significant differences were found in non-traditional lipid parameters among the single, double, and triple positive groups.

Conclusion: First-trimester non-traditional lipid parameters are significant predictors of GDM, particularly when considering fasting blood glucose levels. These parameters offer potential value for early diagnosis.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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