Kangyi Guo, Yipi Xiao, Yun He, Jie Liu, Liang Guo, Aiping Fan, Zheling Zeng, Xiangjuan Zheng, Xiluan Yan
{"title":"超方便快速合成用于人血清多巴胺敏感试纸的FeAg MOGs。","authors":"Kangyi Guo, Yipi Xiao, Yun He, Jie Liu, Liang Guo, Aiping Fan, Zheling Zeng, Xiangjuan Zheng, Xiluan Yan","doi":"10.1007/s00604-025-07565-4","DOIUrl":null,"url":null,"abstract":"<div><p>Metal-organic gels (MOGs) represent the unique category of metal-organic materials, notably distinguished by their expansive specific surface area, highly porous structural frameworks, and readily accessible metallic active sites. This investigation involved the synthesis of FeAg MOGs at ambient temperature using 1,3,5-phenyltricarboxylic acid (H<sub>3</sub>BTC) as a ligand through a simple, one-step method. The resultant FeAg MOGs exhibit excellent oxidase activity, capable of oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) into blue oxTMB. In experimental studies we have discovered that dopamine (DA) exhibits the specific inhibitory effect on the colorimetric response of the FeAg MOGs-TMB system. Based on this a simple, rapid, and sensitive colorimetric method for the selective detection of DA was developed. This methodology possesses a ultra-wide detection range (linear range: 2 μM to 5000 μM) with a detection limit (LOD, S/N = 3) of 1.324 μM. It has proven effective and has been utilized successfully for the quantitative testing of DA in samples of human serum. Furthermore, a test paper has been designed to visually determine DA concentration within a range 2 μM to 1000 μM. The study demonstrates the enormous potential of MOGs for application in the field of colorimetric analysis.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":705,"journal":{"name":"Microchimica Acta","volume":"192 10","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultra-convenient and rapid synthesis of FeAg MOGs for sensitive test strips detection of dopamine in human serum\",\"authors\":\"Kangyi Guo, Yipi Xiao, Yun He, Jie Liu, Liang Guo, Aiping Fan, Zheling Zeng, Xiangjuan Zheng, Xiluan Yan\",\"doi\":\"10.1007/s00604-025-07565-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Metal-organic gels (MOGs) represent the unique category of metal-organic materials, notably distinguished by their expansive specific surface area, highly porous structural frameworks, and readily accessible metallic active sites. This investigation involved the synthesis of FeAg MOGs at ambient temperature using 1,3,5-phenyltricarboxylic acid (H<sub>3</sub>BTC) as a ligand through a simple, one-step method. The resultant FeAg MOGs exhibit excellent oxidase activity, capable of oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) into blue oxTMB. In experimental studies we have discovered that dopamine (DA) exhibits the specific inhibitory effect on the colorimetric response of the FeAg MOGs-TMB system. Based on this a simple, rapid, and sensitive colorimetric method for the selective detection of DA was developed. This methodology possesses a ultra-wide detection range (linear range: 2 μM to 5000 μM) with a detection limit (LOD, S/N = 3) of 1.324 μM. It has proven effective and has been utilized successfully for the quantitative testing of DA in samples of human serum. Furthermore, a test paper has been designed to visually determine DA concentration within a range 2 μM to 1000 μM. The study demonstrates the enormous potential of MOGs for application in the field of colorimetric analysis.</p><h3>Graphical Abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":705,\"journal\":{\"name\":\"Microchimica Acta\",\"volume\":\"192 10\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microchimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00604-025-07565-4\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchimica Acta","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00604-025-07565-4","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Ultra-convenient and rapid synthesis of FeAg MOGs for sensitive test strips detection of dopamine in human serum
Metal-organic gels (MOGs) represent the unique category of metal-organic materials, notably distinguished by their expansive specific surface area, highly porous structural frameworks, and readily accessible metallic active sites. This investigation involved the synthesis of FeAg MOGs at ambient temperature using 1,3,5-phenyltricarboxylic acid (H3BTC) as a ligand through a simple, one-step method. The resultant FeAg MOGs exhibit excellent oxidase activity, capable of oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) into blue oxTMB. In experimental studies we have discovered that dopamine (DA) exhibits the specific inhibitory effect on the colorimetric response of the FeAg MOGs-TMB system. Based on this a simple, rapid, and sensitive colorimetric method for the selective detection of DA was developed. This methodology possesses a ultra-wide detection range (linear range: 2 μM to 5000 μM) with a detection limit (LOD, S/N = 3) of 1.324 μM. It has proven effective and has been utilized successfully for the quantitative testing of DA in samples of human serum. Furthermore, a test paper has been designed to visually determine DA concentration within a range 2 μM to 1000 μM. The study demonstrates the enormous potential of MOGs for application in the field of colorimetric analysis.
期刊介绍：
As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.
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