Huifang Li, Wanying Li, Yiru Tang, Xinsen He, Ying Xiong, Yimou Gong, Ji Lu, Xianchao Pan, Jun Wang, Na Hao, Lin Yang
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Water-Soluble Squaraine-Based NIR Chromofluorogenic Probe for HClO/ClO- Detection in Environmental Waters and Live-Cell Bioimaging.
Hypochlorous acid/hypochlorite (HClO/ClO-), as critical biological reactive oxygen species (ROS), plays essential roles in numerous physiological and pathological processes. To enable sensitive detection of HClO/ClO- in environmental water samples and living cells, a near-infrared (NIR) water-soluble squaraine-based chromofluorogenic probe SO3SQ was developed. SO3SQ exhibits good water solubility, NIR detection wavelength (696 nm/725 nm), high selectivity, rapid response time (within seconds), visible colorimetric response, and minimal cytotoxicity. Furthermore, SO3SQ achieved quantitative HClO/ClO- detection in environmental water samples and realized real-time fluorescence imaging of exogenous/endogenous HClO/ClO- in HepG2 cells. This work provides new ideas for the future design of NIR water-soluble HClO/ClO- probes, while expanding the application of squaraine dyes as HClO/ClO- probes.
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