铜(I)催化缺电子烯烃的Germyl S -磷硫基化

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-30 DOI:10.1002/adsc.70147

Asim Kumar Ghosh, Alakananda Hajra

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引用次数: 0

摘要

采用铜催化的三组分自由基接力反应方案，利用氢化锗和硫代磷得到了缩电子烯烃的二官能化产物。这种转化显示出对官能团的良好耐受性，并且在温和的反应条件下发生，表现出高水平的区域选择性。对照实验表明胚芽基参与了这些转化。

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Cu(I) Catalyzed Germyl S‐Phosphorothiolation of Electron‐Deficient Alkene

A copper‐catalyzed three‐component radical relay protocol is demonstrated for difunctionalization of electron‐withdrawing alkenes using germanium hydride and S‐phosphorothiol to afford the germylphosphorothiolated product. This transformation reveals excellent tolerance for functional groups and occurs under mild reaction conditions, exhibiting a high level of regioselectivity. Control experiments suggest the involvement of germyl radicals in these transformations.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.