纳米治疗中枢神经系统疾病的挑战和机遇

IF 5.1 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Pub Date : 2025-10-01 DOI:10.1039/d5nr02463c

Joel Yong, Karen Hakobyan, Zaheri Mahmud, Daniel Johnson, Jacob Lee, Ashish Diwan, Zi Gu, Gila Moalem-Taylor, Guangzhao Mao

{"title":"纳米治疗中枢神经系统疾病的挑战和机遇","authors":"Joel Yong, Karen Hakobyan, Zaheri Mahmud, Daniel Johnson, Jacob Lee, Ashish Diwan, Zi Gu, Gila Moalem-Taylor, Guangzhao Mao","doi":"10.1039/d5nr02463c","DOIUrl":null,"url":null,"abstract":"Central nervous system (CNS) disorders represent some of the most challenging problems for modern medicine. The complexity of the CNS structure, incomplete understanding of disease, chronic neuroinflammation, and physiological barriers limiting drug delivery all contribute to the difficulty of treating neurological diseases. This review covers the neuroanatomical barriers of the CNS and discusses current treatments, shortcomings of these treatments, recent clinical trials, and opportunities for nanotherapeutic approaches in common CNS disorders. Focus is placed on selected CNS disorders stemming from trauma, neurodegenerative diseases and infectious diseases. The review concludes with summary and perspectives on the nanotherapeutics development highlighting key challenges and future directions for the field.","PeriodicalId":92,"journal":{"name":"Nanoscale","volume":"101 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Challenges and Opportunities in Nanotherapeutics Targeted for Central Nervous System Disorders\",\"authors\":\"Joel Yong, Karen Hakobyan, Zaheri Mahmud, Daniel Johnson, Jacob Lee, Ashish Diwan, Zi Gu, Gila Moalem-Taylor, Guangzhao Mao\",\"doi\":\"10.1039/d5nr02463c\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Central nervous system (CNS) disorders represent some of the most challenging problems for modern medicine. The complexity of the CNS structure, incomplete understanding of disease, chronic neuroinflammation, and physiological barriers limiting drug delivery all contribute to the difficulty of treating neurological diseases. This review covers the neuroanatomical barriers of the CNS and discusses current treatments, shortcomings of these treatments, recent clinical trials, and opportunities for nanotherapeutic approaches in common CNS disorders. Focus is placed on selected CNS disorders stemming from trauma, neurodegenerative diseases and infectious diseases. The review concludes with summary and perspectives on the nanotherapeutics development highlighting key challenges and future directions for the field.\",\"PeriodicalId\":92,\"journal\":{\"name\":\"Nanoscale\",\"volume\":\"101 1\",\"pages\":\"\"},\"PeriodicalIF\":5.1000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanoscale\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1039/d5nr02463c\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanoscale","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1039/d5nr02463c","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

中枢神经系统（CNS）疾病是现代医学最具挑战性的问题之一。中枢神经系统结构的复杂性、对疾病的不完全认识、慢性神经炎症以及限制药物传递的生理障碍都增加了治疗神经系统疾病的难度。这篇综述涵盖了中枢神经系统的神经解剖学障碍，并讨论了目前的治疗方法，这些治疗方法的缺点，最近的临床试验，以及常见中枢神经系统疾病的纳米治疗方法的机会。重点放在选定的中枢神经系统疾病源于创伤，神经退行性疾病和传染病。最后，对纳米治疗的发展进行了总结和展望，指出了该领域面临的主要挑战和未来的发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Challenges and Opportunities in Nanotherapeutics Targeted for Central Nervous System Disorders

Central nervous system (CNS) disorders represent some of the most challenging problems for modern medicine. The complexity of the CNS structure, incomplete understanding of disease, chronic neuroinflammation, and physiological barriers limiting drug delivery all contribute to the difficulty of treating neurological diseases. This review covers the neuroanatomical barriers of the CNS and discusses current treatments, shortcomings of these treatments, recent clinical trials, and opportunities for nanotherapeutic approaches in common CNS disorders. Focus is placed on selected CNS disorders stemming from trauma, neurodegenerative diseases and infectious diseases. The review concludes with summary and perspectives on the nanotherapeutics development highlighting key challenges and future directions for the field.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nanoscale CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

12.10

自引率

3.00%

发文量

1628

审稿时长

1.6 months

期刊介绍： Nanoscale is a high-impact international journal, publishing high-quality research across nanoscience and nanotechnology. Nanoscale publishes a full mix of research articles on experimental and theoretical work, including reviews, communications, and full papers.Highly interdisciplinary, this journal appeals to scientists, researchers and professionals interested in nanoscience and nanotechnology, quantum materials and quantum technology, including the areas of physics, chemistry, biology, medicine, materials, energy/environment, information technology, detection science, healthcare and drug discovery, and electronics.