Enhanced Wound Healing Using Curcumin-Loaded Janus Dressings Fabricated by Femtosecond Laser-Assisted Molding.

Wound dressings play crucial roles in clinical wound management, serving as integral components repairing of damaged skin barriers. Herein, a curcumin-loaded asymmetric-wettability Janus polydimethylsiloxane wound dressing with surface microstructures is developed via a combined approach involving femtosecond laser technology and template replication. The prepared dressing has a hydrophobic outer surface, which offers antifouling and anticontamination characteristics, and an inner surface featuring groove-like micro/nanostructures with a hydrophilic coating, which collectively improve in vitro NIH/3T3 cell proliferation. Furthermore, the structures significantly increase the loading efficiency of curcumin and decrease its release rate, improving the antibacterial properties of the dressing. In vivo evaluation showed that the dressing effectively accelerates wound healing and epithelial tissue regeneration, achieving a wound healing rate of 95.89% within after 13 days of treatment. This study provides valuable insights into the design and development of drug-loaded Janus wound dressings, which have promising potential for improving wound healing outcomes.