Yousaf Abughofah, Shannon L. Risacher, Frederick W. Unverzagt, Martin R. Farlow, Liana G Apostolova, Jared R. Brosch, David G. Clark, Sunu Mathew, Sujuan Gao, Selena Wang, Sophia Wang, Andrew J. Saykin
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引用次数: 0
摘要
认知变化指数（CCI）是一份简短的问卷，用于评估自我和被告知者对认知功能的看法。我们检验了CCI区分认知未受损（CU）老年人和轻度认知障碍（MCI）或阿尔茨海默病（AD）痴呆的能力。方法来自印第安纳州阿尔茨海默病研究中心（IADRC）的485名个体及其研究伙伴完成了20个项目的自我和信息版本的CCI。分析受试者操作特征曲线（Receiver operator characteristic， ROC）来评估CU与功能障碍患者之间的差异。结果使用自我和举报人CCI表区分CU个体与障碍个体时，获得较高的ROC曲线下面积（AUC）值，自我和举报人CCI表的AUC值分别为0.803（95%可信区间[CI] = 0.761-0.844）和0.914 （95% CI = 0.886-0.942）。在MCI和痴呆的多模式评估策略中，CCI可以作为一种有用的筛查工具。使用认知变化指数（CCI）进行痴呆筛查的新颖研究。我们的研究结果表明，CCI可以区分痴呆症患者和非痴呆症患者。这些发现可以与其他筛查工具相关联。可见CCI在早期阿尔茨海默病（AD）的筛查和诊断中具有重要作用。
The Cognitive Change Index in the Alzheimer's Disease Research Center setting: Self- and informant-ratings for perceived cognitive decline
INTRODUCTION
The Cognitive Change Index (CCI) is a brief questionnaire that assesses self and informant perceptions regarding cognitive function. We examined the ability of the CCI to distinguish between cognitively unimpaired (CU) older adults and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia.
METHODS
485 individuals from the Indiana Alzheimer's Disease Research Center (IADRC) and their study partners completed 20-item self and informant versions of the CCI. Receiver operator characteristic (ROC) curves were analyzed to assess differentiation between CU and those with impairment.
RESULTS
High area under the ROC curve (AUC) values were obtained when using the self and informant CCI forms to distinguish CU individuals from those with impairment, with AUC values of 0.803 (95% confidence interval [CI] = 0.761–0.844) and 0.914 (95% CI = 0.886–0.942) for the self and informant forms, respectively.
DISCUSSION
The CCI can serve as a useful screening instrument in the context of a multimodal assessment strategy for MCI and dementia.
Highlights
Novel research that uses the Cognitive Change Index (CCI) for dementia screening.
Our findings suggest that CCI can distinguish those with dementia compared to those without.
These findings can be correlated to other screening instruments.
Results could see the CCI play a role in early Alzheimer's disease (AD) screening and diagnosis.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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