阿尔茨海默病研究中心设置的认知变化指数：感知认知衰退的自我和信息提供者评分。

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-09-30 DOI:10.1002/alz.70754

Yousaf Abughofah, Shannon L. Risacher, Frederick W. Unverzagt, Martin R. Farlow, Liana G Apostolova, Jared R. Brosch, David G. Clark, Sunu Mathew, Sujuan Gao, Selena Wang, Sophia Wang, Andrew J. Saykin

{"title":"阿尔茨海默病研究中心设置的认知变化指数：感知认知衰退的自我和信息提供者评分。","authors":"Yousaf Abughofah, Shannon L. Risacher, Frederick W. Unverzagt, Martin R. Farlow, Liana G Apostolova, Jared R. Brosch, David G. Clark, Sunu Mathew, Sujuan Gao, Selena Wang, Sophia Wang, Andrew J. Saykin","doi":"10.1002/alz.70754","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>The Cognitive Change Index (CCI) is a brief questionnaire that assesses self and informant perceptions regarding cognitive function. We examined the ability of the CCI to distinguish between cognitively unimpaired (CU) older adults and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>485 individuals from the Indiana Alzheimer's Disease Research Center (IADRC) and their study partners completed 20-item self and informant versions of the CCI. Receiver operator characteristic (ROC) curves were analyzed to assess differentiation between CU and those with impairment.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>High area under the ROC curve (AUC) values were obtained when using the self and informant CCI forms to distinguish CU individuals from those with impairment, with AUC values of 0.803 (95% confidence interval [CI] = 0.761–0.844) and 0.914 (95% CI = 0.886–0.942) for the self and informant forms, respectively.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>The CCI can serve as a useful screening instrument in the context of a multimodal assessment strategy for MCI and dementia.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Novel research that uses the Cognitive Change Index (CCI) for dementia screening.</li>\n \n <li>Our findings suggest that CCI can distinguish those with dementia compared to those without.</li>\n \n <li>These findings can be correlated to other screening instruments.</li>\n \n <li>Results could see the CCI play a role in early Alzheimer's disease (AD) screening and diagnosis.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 10","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70754","citationCount":"0","resultStr":"{\"title\":\"The Cognitive Change Index in the Alzheimer's Disease Research Center setting: Self- and informant-ratings for perceived cognitive decline\",\"authors\":\"Yousaf Abughofah, Shannon L. Risacher, Frederick W. Unverzagt, Martin R. Farlow, Liana G Apostolova, Jared R. Brosch, David G. Clark, Sunu Mathew, Sujuan Gao, Selena Wang, Sophia Wang, Andrew J. Saykin\",\"doi\":\"10.1002/alz.70754\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>The Cognitive Change Index (CCI) is a brief questionnaire that assesses self and informant perceptions regarding cognitive function. We examined the ability of the CCI to distinguish between cognitively unimpaired (CU) older adults and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>485 individuals from the Indiana Alzheimer's Disease Research Center (IADRC) and their study partners completed 20-item self and informant versions of the CCI. Receiver operator characteristic (ROC) curves were analyzed to assess differentiation between CU and those with impairment.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>High area under the ROC curve (AUC) values were obtained when using the self and informant CCI forms to distinguish CU individuals from those with impairment, with AUC values of 0.803 (95% confidence interval [CI] = 0.761–0.844) and 0.914 (95% CI = 0.886–0.942) for the self and informant forms, respectively.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>The CCI can serve as a useful screening instrument in the context of a multimodal assessment strategy for MCI and dementia.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Novel research that uses the Cognitive Change Index (CCI) for dementia screening.</li>\\n \\n <li>Our findings suggest that CCI can distinguish those with dementia compared to those without.</li>\\n \\n <li>These findings can be correlated to other screening instruments.</li>\\n \\n <li>Results could see the CCI play a role in early Alzheimer's disease (AD) screening and diagnosis.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 10\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70754\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70754\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70754","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

认知变化指数（CCI）是一份简短的问卷，用于评估自我和被告知者对认知功能的看法。我们检验了CCI区分认知未受损（CU）老年人和轻度认知障碍（MCI）或阿尔茨海默病（AD）痴呆的能力。方法来自印第安纳州阿尔茨海默病研究中心（IADRC）的485名个体及其研究伙伴完成了20个项目的自我和信息版本的CCI。分析受试者操作特征曲线（Receiver operator characteristic， ROC）来评估CU与功能障碍患者之间的差异。结果使用自我和举报人CCI表区分CU个体与障碍个体时，获得较高的ROC曲线下面积（AUC）值，自我和举报人CCI表的AUC值分别为0.803（95%可信区间[CI] = 0.761-0.844）和0.914 （95% CI = 0.886-0.942）。在MCI和痴呆的多模式评估策略中，CCI可以作为一种有用的筛查工具。使用认知变化指数（CCI）进行痴呆筛查的新颖研究。我们的研究结果表明，CCI可以区分痴呆症患者和非痴呆症患者。这些发现可以与其他筛查工具相关联。可见CCI在早期阿尔茨海默病（AD）的筛查和诊断中具有重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The Cognitive Change Index in the Alzheimer's Disease Research Center setting: Self- and informant-ratings for perceived cognitive decline

INTRODUCTION

The Cognitive Change Index (CCI) is a brief questionnaire that assesses self and informant perceptions regarding cognitive function. We examined the ability of the CCI to distinguish between cognitively unimpaired (CU) older adults and those with mild cognitive impairment (MCI) or Alzheimer's disease (AD) dementia.

METHODS

485 individuals from the Indiana Alzheimer's Disease Research Center (IADRC) and their study partners completed 20-item self and informant versions of the CCI. Receiver operator characteristic (ROC) curves were analyzed to assess differentiation between CU and those with impairment.

RESULTS

High area under the ROC curve (AUC) values were obtained when using the self and informant CCI forms to distinguish CU individuals from those with impairment, with AUC values of 0.803 (95% confidence interval [CI] = 0.761–0.844) and 0.914 (95% CI = 0.886–0.942) for the self and informant forms, respectively.

DISCUSSION

The CCI can serve as a useful screening instrument in the context of a multimodal assessment strategy for MCI and dementia.

Highlights

Novel research that uses the Cognitive Change Index (CCI) for dementia screening.
Our findings suggest that CCI can distinguish those with dementia compared to those without.
These findings can be correlated to other screening instruments.
Results could see the CCI play a role in early Alzheimer's disease (AD) screening and diagnosis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.