Teodora Z. Markova, Corrina S. Fonseca, Claire J. Ciampa, Alice Murphy, Susan Landau, Theresa M. Harrison, Anne S. Berry, for the Alzheimer's Disease Neuroimaging Initiative
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We report secondary analyses from the Berkeley Aging Cohort Study (BACS).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Longitudinal increases in depressive symptoms were associated with higher baseline FTP and increasing FTP in the amygdala. Relationships between FTP and depressive symptoms were strongest in <i>APOE</i> ε4 carriers, with moderation effects replicating in BACS. Entorhinal FTP did not show associations with depressive symptoms beyond variance explained by the amygdala but showed some specific associations with memory decline.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Our findings indicate the strongest coupling between tau accumulation and depressive symptoms in <i>APOE</i> ε4 carriers and reinforce the importance of amygdala tau in understanding neuropsychiatric changes in older adults.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>There is a lack of research focused on the role of tau in the amygdala in cognitively normal older adults.</li>\n \n <li>Amygdala tau is related to both worsening depressive symptoms and declining memory performance.</li>\n \n <li><i>APOE</i> ε4 carriers seem to drive positive tau-depressive symptom associations.</li>\n \n <li>Focusing on the amygdala tau is useful for understanding neuropsychiatric trajectories in cognitively unimpaired older adults.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 10","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70740","citationCount":"0","resultStr":"{\"title\":\"Defining the contributions of tau pathology in the amygdala to increasing depressive symptoms in aging\",\"authors\":\"Teodora Z. 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We report secondary analyses from the Berkeley Aging Cohort Study (BACS).</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Longitudinal increases in depressive symptoms were associated with higher baseline FTP and increasing FTP in the amygdala. Relationships between FTP and depressive symptoms were strongest in <i>APOE</i> ε4 carriers, with moderation effects replicating in BACS. Entorhinal FTP did not show associations with depressive symptoms beyond variance explained by the amygdala but showed some specific associations with memory decline.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>Our findings indicate the strongest coupling between tau accumulation and depressive symptoms in <i>APOE</i> ε4 carriers and reinforce the importance of amygdala tau in understanding neuropsychiatric changes in older adults.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>There is a lack of research focused on the role of tau in the amygdala in cognitively normal older adults.</li>\\n \\n <li>Amygdala tau is related to both worsening depressive symptoms and declining memory performance.</li>\\n \\n <li><i>APOE</i> ε4 carriers seem to drive positive tau-depressive symptom associations.</li>\\n \\n <li>Focusing on the amygdala tau is useful for understanding neuropsychiatric trajectories in cognitively unimpaired older adults.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 10\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70740\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70740\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70740","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Defining the contributions of tau pathology in the amygdala to increasing depressive symptoms in aging
BACKGROUND
Amygdala tau accumulates in cognitively normal individuals and may contribute to neuropsychiatric changes.
METHODS
Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we investigated relationships among cross-sectional and longitudinal tau ([18F]Flortaucipir [FTP] positron emission tomography), changes in depressive symptoms and memory, and amyloid beta and apolipoprotein E (APOE) ε4 status. We report secondary analyses from the Berkeley Aging Cohort Study (BACS).
RESULTS
Longitudinal increases in depressive symptoms were associated with higher baseline FTP and increasing FTP in the amygdala. Relationships between FTP and depressive symptoms were strongest in APOE ε4 carriers, with moderation effects replicating in BACS. Entorhinal FTP did not show associations with depressive symptoms beyond variance explained by the amygdala but showed some specific associations with memory decline.
DISCUSSION
Our findings indicate the strongest coupling between tau accumulation and depressive symptoms in APOE ε4 carriers and reinforce the importance of amygdala tau in understanding neuropsychiatric changes in older adults.
Highlights
There is a lack of research focused on the role of tau in the amygdala in cognitively normal older adults.
Amygdala tau is related to both worsening depressive symptoms and declining memory performance.
APOE ε4 carriers seem to drive positive tau-depressive symptom associations.
Focusing on the amygdala tau is useful for understanding neuropsychiatric trajectories in cognitively unimpaired older adults.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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