Comparison of Metabolic Profile and Anthropometric Measurements among Obese Children and Adolescents with Different Grades of Fatty Liver Disease: An Experience in a Tertiary Care Centre in Bangladesh.

A cross sectional study was conducted among 79 children and adolescents in Paediatric Endocrine Outpatient Department (OPD) of Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital, a tertiary care centre in Dhaka, Bangladesh. Children and adolescents of 8 to 18 years of age with simple obesity who visited during the period of 1st January 2018 to 30th June 2018 were included in this study. The study was done to determine the percentage of different grades of fatty liver disease and to compare metabolic profiles and anthropometric measurements among obese children and adolescents with different grades of fatty liver disease. Fatty liver disease was identified and it's grading was done by Real-time ultrasonography of hepatobiliary system. Total 24 obese children (30.4%) had fatty liver disease among 79 patients. Majority of them (54.2%) had mild fatty liver disease followed by moderate fatty liver disease (41.6%). Severe fatty liver disease was found in only one child. Fasting blood sugar (p=0.031) and SGPT level (p=0.001) were significantly higher among children and adolescents with fatty liver disease in comparison to children without it. When comparison was done in different grades of fatty liver disease, triglyceride level (p=0.033) and diastolic hypertension (p=0.016) was significantly higher in children having moderate fatty liver disease. There was no significant difference in anthropometric measurements among children having different grades of fatty liver disease.