Angela Klingmüller, Jonathan Steinke, Jan Rybniker, Isabelle Suárez
{"title":"(肺外结核病)。","authors":"Angela Klingmüller, Jonathan Steinke, Jan Rybniker, Isabelle Suárez","doi":"10.1055/a-2597-9679","DOIUrl":null,"url":null,"abstract":"<p><p>In 2023, tuberculosis (TB) caused 1.25 million deaths among 10.8 million cases, remaining the deadliest infectious disease worldwide. In Germany, incidence declined for decades but rose slightly in 2022-2023, driven mainly by migration from high-prevalence countries (e.g., Syria, Afghanistan, Ukraine). While most cases are pulmonary TB (PTB), 22.8% are extrapulmonary TB (EPTB), which can affect any organ and is often hard to diagnose due to nonspecific symptoms. Diagnosis uses microscopy, PCR, and culture; treatment typically lasts at least 6 months, extended for CNS, bone, or miliary TB. Treatment response is assessed clinically and radiologically; reliable blood-based markers are urgently needed.</p>","PeriodicalId":93975,"journal":{"name":"Deutsche medizinische Wochenschrift (1946)","volume":"150 20","pages":"1189-1196"},"PeriodicalIF":0.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Extrapulmonary tuberculosis].\",\"authors\":\"Angela Klingmüller, Jonathan Steinke, Jan Rybniker, Isabelle Suárez\",\"doi\":\"10.1055/a-2597-9679\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In 2023, tuberculosis (TB) caused 1.25 million deaths among 10.8 million cases, remaining the deadliest infectious disease worldwide. In Germany, incidence declined for decades but rose slightly in 2022-2023, driven mainly by migration from high-prevalence countries (e.g., Syria, Afghanistan, Ukraine). While most cases are pulmonary TB (PTB), 22.8% are extrapulmonary TB (EPTB), which can affect any organ and is often hard to diagnose due to nonspecific symptoms. Diagnosis uses microscopy, PCR, and culture; treatment typically lasts at least 6 months, extended for CNS, bone, or miliary TB. Treatment response is assessed clinically and radiologically; reliable blood-based markers are urgently needed.</p>\",\"PeriodicalId\":93975,\"journal\":{\"name\":\"Deutsche medizinische Wochenschrift (1946)\",\"volume\":\"150 20\",\"pages\":\"1189-1196\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Deutsche medizinische Wochenschrift (1946)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1055/a-2597-9679\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Deutsche medizinische Wochenschrift (1946)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2597-9679","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
In 2023, tuberculosis (TB) caused 1.25 million deaths among 10.8 million cases, remaining the deadliest infectious disease worldwide. In Germany, incidence declined for decades but rose slightly in 2022-2023, driven mainly by migration from high-prevalence countries (e.g., Syria, Afghanistan, Ukraine). While most cases are pulmonary TB (PTB), 22.8% are extrapulmonary TB (EPTB), which can affect any organ and is often hard to diagnose due to nonspecific symptoms. Diagnosis uses microscopy, PCR, and culture; treatment typically lasts at least 6 months, extended for CNS, bone, or miliary TB. Treatment response is assessed clinically and radiologically; reliable blood-based markers are urgently needed.
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