中老年人血清尿酸/肌酐比值与抑郁症状之间的关系:来自中国和美国两项大型人群研究的证据

IF 1.3 4区 医学 Q4 PSYCHIATRY
Jiang-Yu Tu, Meng-Qin Tu
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引用次数: 0

摘要

目的:越来越多的证据表明,血清尿酸(SUA)可能通过与氧化应激有关的机制调节抑郁症状。然而,血清尿酸/肌酐比值(SUA/Cr)——反映净尿酸生成的生物标志物——是否与中老年人群的抑郁症状有关仍不得而知。方法利用两个国家具有全国代表性的样本进行纵向和横断面分析:中国健康与退休纵向研究(CHARLS)进行纵向评估,美国国家健康与营养检查调查(NHANES)进行横断面评估。采用多变量Cox和logistic回归分析检验SUA/Cr与抑郁症状的关系。剂量-反应关系采用限制性三次样条(RCS)建模,敏感性分析评估结果的稳定性。结果CHARLS (N = 4317)多变量Cox回归显示SUA/Cr与抑郁症状呈负相关(p线性)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Serum Uric Acid/Creatinine Ratio and Depressive Symptoms in Middle-Aged and Older Adults: Evidence from Two Large Population-Based Studies in China and the United States.

ObjectiveEmerging evidence suggests that serum uric acid (SUA) can modulate depressive symptoms, potentially via mechanisms involving oxidative stress. However, whether the serum uric acid/creatinine ratio (SUA/Cr)-a biomarker reflecting net uric acid production-is linked to depressive symptoms in middle-to-late life populations remains unknown.MethodsLongitudinal and cross-sectional analyses were conducted utilizing nationally representative samples from two countries: the China Health and Retirement Longitudinal Study (CHARLS) for longitudinal assessment and the U.S. National Health and Nutrition Examination Survey (NHANES) for cross-sectional evaluation. Multivariable Cox and logistic regression analyses were employed to examine the relationship between the SUA/Cr and depressive symptoms. Dose-response relationships were modeled using restricted cubic splines (RCS), while sensitivity analyses assessed the stability of results. ResultsFrom CHARLS (N = 4317), multivariable Cox regression revealed an inverse relationship between SUA/Cr and depressive symptoms (P-linearity<0.05), with each 1-unit increase linked to a 3% lower risk (HR = 0.97, 95% CI = 0.94-0.99). Q4 showed reduced risk vs Q1 (HR = 0.87, 95% CI = 0.77-0.97). NHANES analysis of cross-sectional data (N = 18 677) confirmed this inverse association (P- linearity<0.05), with a 6% lower odds of significant depression per 1-unit SUA/Cr increase (OR = 0.94, 95% CI = 0.87-1.03). Q3 and Q4 had significantly lower odds vs Q1 (OR = 0.78, 95% CI = 0.64-0.95, and OR = 0.79, 95% CI = 0.65-0.98, respectively). RCS curves confirmed dose-response relationships in both cohorts. Findings remained consistent in sensitivity analyses.ConclusionDepressive symptoms in middle-to-late adulthood were found to be negatively correlated with SUA/Cr levels in longitudinal and cross-sectional analyses. These findings suggest that SUA/Cr levels may function as a biological indicator to facilitate early detection and proactive intervention for depressive disorders.

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来源期刊
CiteScore
3.00
自引率
5.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...
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