{"title":"2023-2024年北京市儿科患者诺如病毒GII基因群流行病学及遗传多样性","authors":"Junhong Ai, Qiliang Li, Ke Xu, Yuxuan Li, Ying Liu, Luci Huang, Wenqi Song, Zhengde Xie","doi":"10.1186/s12985-025-02927-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Norovirus is an important cause of viral acute gastroenteritis (AGE) worldwide.</p><p><strong>Methods: </strong>In order to characterize the molecular epidemiology and genetic diversity of norovirus in children in Beijing, 3634 anal swab samples of AGE patients from January 2023 to December 2024 were analyzed. Norovirus was detected using RT-PCR and genotyped by sequencing the partial RdRp and VP1 region.</p><p><strong>Results: </strong>During the two-year period, norovirus was detected in 19.6% of AGE cases, with the highest detection rate in children under 3 years of age. GII.4 and GII.P16 were the dominant genotypes of VP1 and RdRp, with a detection rate of 36.39% and 44.59%, respectively. According to the dual-typing system combined the RdRp and VP1, the dominant genotypes of norovirus changed between 2023 and 2024. In 2023, the most common genotype was GII.3[P12] (39.15%), followed by GII.4 Sydney[P16] (32.34%) and GII.4 Sydney[P31] (15.32%). However, in 2024, the dominant genotype was GII.17[P17] (41.43%), followed by GII.4 Sydney[P16] (34.29%) and GII.3[P12] (20.0%). The GII.17 variants in this study were divided into two clusters: cluster IIIa and IIIb, which shared high nucleotide identity with GII.17 variant emerged in 2014/2015. Significantly, GII.4 Sydney[P31] and novel GII.4 Sydney[P16] variants co-circulating in this region from 2023 to 2024.</p><p><strong>Conclusion: </strong>The data provided useful information on the molecular epidemiology of norovirus in sporadic AGE among children and highlighted the necessary to continuously monitor the epidemiological characteristics of norovirus associated AGE.</p>","PeriodicalId":23616,"journal":{"name":"Virology Journal","volume":"22 1","pages":"310"},"PeriodicalIF":4.0000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482263/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epidemiology and genetic diversity of norovirus GII genogroups among pediatric patients in Beijing, China, during 2023-2024.\",\"authors\":\"Junhong Ai, Qiliang Li, Ke Xu, Yuxuan Li, Ying Liu, Luci Huang, Wenqi Song, Zhengde Xie\",\"doi\":\"10.1186/s12985-025-02927-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Norovirus is an important cause of viral acute gastroenteritis (AGE) worldwide.</p><p><strong>Methods: </strong>In order to characterize the molecular epidemiology and genetic diversity of norovirus in children in Beijing, 3634 anal swab samples of AGE patients from January 2023 to December 2024 were analyzed. Norovirus was detected using RT-PCR and genotyped by sequencing the partial RdRp and VP1 region.</p><p><strong>Results: </strong>During the two-year period, norovirus was detected in 19.6% of AGE cases, with the highest detection rate in children under 3 years of age. GII.4 and GII.P16 were the dominant genotypes of VP1 and RdRp, with a detection rate of 36.39% and 44.59%, respectively. According to the dual-typing system combined the RdRp and VP1, the dominant genotypes of norovirus changed between 2023 and 2024. In 2023, the most common genotype was GII.3[P12] (39.15%), followed by GII.4 Sydney[P16] (32.34%) and GII.4 Sydney[P31] (15.32%). However, in 2024, the dominant genotype was GII.17[P17] (41.43%), followed by GII.4 Sydney[P16] (34.29%) and GII.3[P12] (20.0%). The GII.17 variants in this study were divided into two clusters: cluster IIIa and IIIb, which shared high nucleotide identity with GII.17 variant emerged in 2014/2015. Significantly, GII.4 Sydney[P31] and novel GII.4 Sydney[P16] variants co-circulating in this region from 2023 to 2024.</p><p><strong>Conclusion: </strong>The data provided useful information on the molecular epidemiology of norovirus in sporadic AGE among children and highlighted the necessary to continuously monitor the epidemiological characteristics of norovirus associated AGE.</p>\",\"PeriodicalId\":23616,\"journal\":{\"name\":\"Virology Journal\",\"volume\":\"22 1\",\"pages\":\"310\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482263/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virology Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12985-025-02927-z\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12985-025-02927-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VIROLOGY","Score":null,"Total":0}
Epidemiology and genetic diversity of norovirus GII genogroups among pediatric patients in Beijing, China, during 2023-2024.
Background: Norovirus is an important cause of viral acute gastroenteritis (AGE) worldwide.
Methods: In order to characterize the molecular epidemiology and genetic diversity of norovirus in children in Beijing, 3634 anal swab samples of AGE patients from January 2023 to December 2024 were analyzed. Norovirus was detected using RT-PCR and genotyped by sequencing the partial RdRp and VP1 region.
Results: During the two-year period, norovirus was detected in 19.6% of AGE cases, with the highest detection rate in children under 3 years of age. GII.4 and GII.P16 were the dominant genotypes of VP1 and RdRp, with a detection rate of 36.39% and 44.59%, respectively. According to the dual-typing system combined the RdRp and VP1, the dominant genotypes of norovirus changed between 2023 and 2024. In 2023, the most common genotype was GII.3[P12] (39.15%), followed by GII.4 Sydney[P16] (32.34%) and GII.4 Sydney[P31] (15.32%). However, in 2024, the dominant genotype was GII.17[P17] (41.43%), followed by GII.4 Sydney[P16] (34.29%) and GII.3[P12] (20.0%). The GII.17 variants in this study were divided into two clusters: cluster IIIa and IIIb, which shared high nucleotide identity with GII.17 variant emerged in 2014/2015. Significantly, GII.4 Sydney[P31] and novel GII.4 Sydney[P16] variants co-circulating in this region from 2023 to 2024.
Conclusion: The data provided useful information on the molecular epidemiology of norovirus in sporadic AGE among children and highlighted the necessary to continuously monitor the epidemiological characteristics of norovirus associated AGE.
期刊介绍：
Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies.
The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.
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