普伐他汀治疗放射性肢体纤维化：单中心经验。

IF 2.3 3区医学 Q2 HEMATOLOGY

Pediatric Blood & Cancer Pub Date : 2025-09-29 DOI:10.1002/pbc.32084

Rachel Offenbacher, Lara Fabish, Alice Lee, Rui Yang, Bang Hoang, David S. Geller, Jana L. Fox, David M. Loeb, Alissa Baker

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引用次数: 0

摘要

放射治疗（RT）是几种肉瘤的主要治疗方法。辐射诱导纤维化（RIF）是放疗常见的副作用，发生率约为80%。RIF是由产生胶原蛋白和细胞外基质成分的肌成纤维细胞过度增殖引起的，再加上重塑酶的减少。用普伐他汀靶向这一途径来预防和改善RIF已被证明可以改善头颈癌患者的预后。我们分享我们的单中心经验，使用普伐他汀治疗涉及关节的RIF，包括发生RIF的肉瘤儿童，以及预防性用药人群。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pravastatin for Radiation-Induced Fibrosis of the Extremity: A Single-Center Experience

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Pravastatin for Radiation-Induced Fibrosis of the Extremity: A Single-Center Experience

Radiation therapy (RT) is a mainstay of treatment for several sarcomas. Radiation-induced fibrosis (RIF) is a common side effect of RT with an incidence of approximately 80%. RIF is caused by excessive proliferation of myofibroblasts, which produce collagen and extracellular matrix components, coupled with a reduction of remodeling enzymes. Targeting this pathway with pravastatin to prevent and ameliorate RIF has been shown to improve outcomes in patients with head and neck cancer. We share our single-center experience using pravastatin to treat RIF involving the joints in children with sarcomas who developed RIF, as well as in a population administered prophylactically.

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来源期刊

Pediatric Blood & Cancer 医学-小儿科

CiteScore

4.90

自引率

9.40%

发文量

546

审稿时长

1.5 months

期刊介绍： Pediatric Blood & Cancer publishes the highest quality manuscripts describing basic and clinical investigations of blood disorders and malignant diseases of childhood including diagnosis, treatment, epidemiology, etiology, biology, and molecular and clinical genetics of these diseases as they affect children, adolescents, and young adults. Pediatric Blood & Cancer will also include studies on such treatment options as hematopoietic stem cell transplantation, immunology, and gene therapy.