{"title":"膳食色氨酸在雄性白化wistar大鼠记忆调节中的双重作用——血清素能信号和犬尿氨酸途径的协同调节。","authors":"Huma Ikram, Shahla Perveen, Darakhshan J Haleem","doi":"10.1080/1028415X.2025.2565703","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the impact of tryptophan metabolism on synaptic plasticity, neurogenesis, and memory consolidation using a combined biochemical and behavioral approach.</p><p><strong>Methods: </strong>We treated male Albino Wistar rats with different doses of tryptophan for 4 weeks followed by weekly assessment of memory performance through Morris Water Maze (MWM) and Novel Object Recognition (NOR) tests. High-performance liquid chromatography (HPLC) was used to quantify serotonin and metabolites in hippocampus, while kynurenine in plasma samples.</p><p><strong>Results: </strong>Our findings reveal that low dose of tryptophan improved learning and memory in rats while high dose significantly impaired spatial and recognition memory, correlating with reduced serotonin and increased kynurenic acid levels. Conversely, tryptophan supplementation at high dose was also accompanied by increased Interleukin-6 (IL-6), Interleukin-1β (IL-1β) and Tumor Necrosis Factor-α (TNF-α) expression in brain.</p><p><strong>Discussion: </strong>These results highlight the dual role of tryptophan in memory regulation - through serotonergic signaling and kynurenine pathway modulation - providing potential therapeutic targets for memory-related disorders such as Alzheimer's and Parkinson's-related dementia.</p>","PeriodicalId":19423,"journal":{"name":"Nutritional Neuroscience","volume":" ","pages":"1-15"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dual role of dietary tryptophan on memory regulation in male albino wistar rats - synergistic modulation of serotonergic signaling and kynurenine pathway.\",\"authors\":\"Huma Ikram, Shahla Perveen, Darakhshan J Haleem\",\"doi\":\"10.1080/1028415X.2025.2565703\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study investigates the impact of tryptophan metabolism on synaptic plasticity, neurogenesis, and memory consolidation using a combined biochemical and behavioral approach.</p><p><strong>Methods: </strong>We treated male Albino Wistar rats with different doses of tryptophan for 4 weeks followed by weekly assessment of memory performance through Morris Water Maze (MWM) and Novel Object Recognition (NOR) tests. High-performance liquid chromatography (HPLC) was used to quantify serotonin and metabolites in hippocampus, while kynurenine in plasma samples.</p><p><strong>Results: </strong>Our findings reveal that low dose of tryptophan improved learning and memory in rats while high dose significantly impaired spatial and recognition memory, correlating with reduced serotonin and increased kynurenic acid levels. Conversely, tryptophan supplementation at high dose was also accompanied by increased Interleukin-6 (IL-6), Interleukin-1β (IL-1β) and Tumor Necrosis Factor-α (TNF-α) expression in brain.</p><p><strong>Discussion: </strong>These results highlight the dual role of tryptophan in memory regulation - through serotonergic signaling and kynurenine pathway modulation - providing potential therapeutic targets for memory-related disorders such as Alzheimer's and Parkinson's-related dementia.</p>\",\"PeriodicalId\":19423,\"journal\":{\"name\":\"Nutritional Neuroscience\",\"volume\":\" \",\"pages\":\"1-15\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutritional Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/1028415X.2025.2565703\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutritional Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/1028415X.2025.2565703","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Dual role of dietary tryptophan on memory regulation in male albino wistar rats - synergistic modulation of serotonergic signaling and kynurenine pathway.
Objective: This study investigates the impact of tryptophan metabolism on synaptic plasticity, neurogenesis, and memory consolidation using a combined biochemical and behavioral approach.
Methods: We treated male Albino Wistar rats with different doses of tryptophan for 4 weeks followed by weekly assessment of memory performance through Morris Water Maze (MWM) and Novel Object Recognition (NOR) tests. High-performance liquid chromatography (HPLC) was used to quantify serotonin and metabolites in hippocampus, while kynurenine in plasma samples.
Results: Our findings reveal that low dose of tryptophan improved learning and memory in rats while high dose significantly impaired spatial and recognition memory, correlating with reduced serotonin and increased kynurenic acid levels. Conversely, tryptophan supplementation at high dose was also accompanied by increased Interleukin-6 (IL-6), Interleukin-1β (IL-1β) and Tumor Necrosis Factor-α (TNF-α) expression in brain.
Discussion: These results highlight the dual role of tryptophan in memory regulation - through serotonergic signaling and kynurenine pathway modulation - providing potential therapeutic targets for memory-related disorders such as Alzheimer's and Parkinson's-related dementia.
期刊介绍：
Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.
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