高清晰度经颅直流电刺激对轻度认知障碍患者脑白质微结构及执行功能影响的初步证据。

IF 1.7 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2025-11-05 Epub Date: 2025-09-16 DOI:10.1097/WNR.0000000000002216

Fangmei He, Herong He, Chaolin Teng, Chunxiao Ren, Libin Wang, Qian Yang, Huan Li

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引用次数: 0

摘要

背景：轻度认知障碍（MCI）是在阿尔茨海默病进展之前进行干预的关键窗口。本研究探讨了针对左背外侧前额叶皮质（L-DLPFC）的高清晰度经颅直流电刺激（HD-tDCS）是否能调节白质微观结构，从而影响认知功能。方法：24例MCI患者在L-DLPFC上接受10次活动HD-tDCS。使用弥散张量成像（DTI）评估白质完整性，量化皮质脊髓束（CSTs）和丘脑前辐射（ATR）的分数各向异性。认知功能在基线和干预后分别用造径测试B （TMT-B）、简易精神状态检查（MMSE）和蒙特利尔认知评估（MoCA）进行评估。40名健康对照者提供了基线DTI数据。结果：在基线时，与健康对照相比，MCI患者双侧CST和ATR的分数各向异性显著降低。在HD-tDCS后，观察到这些束的分数各向异性增加。虽然MMSE和MoCA得分没有明显变化，但TMT-B表现似乎有所改善。值得注意的是，左侧ATR各向异性分数的增加与TMT-B表现的改善有关（r = 0.467， P）。结论：以L-DLPFC为靶点的HD-tDCS可能促进白质束的微结构重塑，这可以通过皮质脊髓和丘脑前通路的各向异性分数的增加来证明。虽然整体认知测量保持稳定，但观察到执行功能（TMT-B）改善的趋势，可能与左ATR分数各向异性增强有关。这使得HD-tDCS成为MCI的候选神经调节干预措施，需要进一步研究以确认功能结果。

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Preliminary evidence for high-definition transcranial direct current stimulation effects on white matter microstructure and executive function in mild cognitive impairment.

Background: Mild cognitive impairment (MCI) represents a critical window for intervention before Alzheimer's disease progression. This study investigated whether high-definition transcranial direct current stimulation (HD-tDCS) targeting the left dorsolateral prefrontal cortex (L-DLPFC) could modulate white matter microstructure and thereby influence cognitive function.

Methods: Twenty-four patients with MCI received 10 sessions of active HD-tDCS over the L-DLPFC. White matter integrity was assessed using diffusion tensor imaging (DTI) to quantify fractional anisotropy in corticospinal tracts (CSTs) and anterior thalamic radiations (ATR). Cognitive function was evaluated with the trail making test B (TMT-B), mini-mental state examination (MMSE), and Montreal cognitive assessment (MoCA) at baseline and postintervention. Forty healthy controls provided baseline DTI data.

Results: At baseline, patients with MCI showed significantly reduced fractional anisotropy in the bilateral CST and ATR compared with healthy controls. Following HD-tDCS, increases in fractional anisotropy were observed in these tracts. While MMSE and MoCA scores showed no significant change, TMT-B performance appeared to improve. Notably, increased fractional anisotropy in the left ATR showed an association with improved TMT-B performance (r = 0.467, P < 0.05).

Conclusion: The findings suggest that HD-tDCS targeting the L-DLPFC may promote microstructural remodeling in white matter tracts, evidenced by elevated fractional anisotropy within the corticospinal and anterior thalamic pathways. While global cognitive measures remained stable, a trend toward improved executive function (TMT-B) was observed, potentially associated with left ATR fractional anisotropy enhancement. This positions HD-tDCS as a candidate neuromodulatory intervention for MCI, warranting further investigation to confirm functional outcomes.

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.