非激素受体基底蛋白和调控microrna在乳腺癌中的多效性作用。

IF 7.6 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2025-09-29 DOI:10.1038/s41523-025-00827-7

Kelsey Bruce, Michael Kerin, Vinitha Richard

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引用次数: 0

摘要

乳腺癌是一种全球性的异质性疾病。Basigin （BSG）是一种在乳腺肿瘤微环境中具有多种功能的跨膜蛋白。利用癌症的特征，我们探讨BSG在乳腺癌中的多效性作用。此外，我们研究了BSG的细胞相互作用和BSG的分子调节因子。BSG具有潜在的预后作用，是新的治疗干预措施的候选靶点。

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The pleiotropic roles of non-hormonal receptor basigin and regulatory microRNAs in breast cancer.

Breast cancer is a heterogeneous disease with global reach. Basigin (BSG) is a transmembrane protein with multifunctional roles in the breast tumor microenvironment. Using the hallmarks of cancer, we explore the pleiotropic roles of BSG in breast cancer. Further, we examine the cellular interactants of BSG and the molecular regulators of BSG. BSG has the potential to play a prognostic role and is a candidate target for new therapeutic interventions.

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.