{"title":"圆度指数与全因死亡率和心血管死亡率：来自日本成年人的发现和初步荟萃分析。","authors":"Kazuma Murakami, Ryosuke Fujii, Yoshiki Tsuboi, Hiroshi Okumiyama, Riku Umematsu, Koji Suzuki","doi":"10.1016/j.tjnut.2025.09.031","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Although body roundness index (BRI) is gaining attention as an indicator of abdominal obesity, evidence on this indicator is still sparse.</p><p><strong>Objective: </strong>We aimed to summarize basic information about BRI in a Japanese population and to examine associations of BRI with all-cause and cardiovascular disease (CVD) mortality with a preliminary meta-analysis.</p><p><strong>Methods: </strong>This population-based cohort study included participants (mean age of 58.4 years [min, max: 40, 89], 37.8% men) in health check-up programs between 2004 and 2018, and we followed up until December 31, 2023. BRI was calculated by a conventional formula for height (cm) and waist circumference (cm). CVD mortality was defined as mortality with ICD-10 codes of I00-I99. Hazard ratios were estimated for all-cause and CVD mortality using Cox proportional hazards regression models.</p><p><strong>Results: </strong>During the follow-up period (median: 13.3 years), 206 individuals died, and 47 individuals died from CVD. Women had a wider distribution of BRI (median: 3.72; IQR: 2.84, 4.88) compared with men (median: 3.54; IQR: 2.88, 4.19). BRI increased from the 40-49 age group (median: 3.24; IQR: 2.42, 4.08) to those over 70 years old (median: 4.22; IQR: 3.20, 5.32). Compared with Q1, HRs (95% CI) in Q3 were lower for both all-cause mortality (HR: 0.64, 95% CI: 0.43, 0.96) and CVD mortality (HR: 0.27, 95% CI: 0.09, 0.78). Preliminary meta-analysis also supported a similar U-shaped association of BRI with mortality with a HR in Q3 of 0.85 (95% CI: 0.75, 0.95) compared with Q1.</p><p><strong>Conclusions: </strong>BRI varies across age groups and between sexes in a Japanese population. Both our results and this meta-analysis suggest that BRI has U-shaped associations with all-cause and CVD mortality.</p><p><strong>Prospero registry no: </strong>1149845.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Body roundness index and all-cause and cardiovascular mortality: findings from Japanese adults and preliminary meta-analysis.\",\"authors\":\"Kazuma Murakami, Ryosuke Fujii, Yoshiki Tsuboi, Hiroshi Okumiyama, Riku Umematsu, Koji Suzuki\",\"doi\":\"10.1016/j.tjnut.2025.09.031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Although body roundness index (BRI) is gaining attention as an indicator of abdominal obesity, evidence on this indicator is still sparse.</p><p><strong>Objective: </strong>We aimed to summarize basic information about BRI in a Japanese population and to examine associations of BRI with all-cause and cardiovascular disease (CVD) mortality with a preliminary meta-analysis.</p><p><strong>Methods: </strong>This population-based cohort study included participants (mean age of 58.4 years [min, max: 40, 89], 37.8% men) in health check-up programs between 2004 and 2018, and we followed up until December 31, 2023. BRI was calculated by a conventional formula for height (cm) and waist circumference (cm). CVD mortality was defined as mortality with ICD-10 codes of I00-I99. Hazard ratios were estimated for all-cause and CVD mortality using Cox proportional hazards regression models.</p><p><strong>Results: </strong>During the follow-up period (median: 13.3 years), 206 individuals died, and 47 individuals died from CVD. Women had a wider distribution of BRI (median: 3.72; IQR: 2.84, 4.88) compared with men (median: 3.54; IQR: 2.88, 4.19). BRI increased from the 40-49 age group (median: 3.24; IQR: 2.42, 4.08) to those over 70 years old (median: 4.22; IQR: 3.20, 5.32). Compared with Q1, HRs (95% CI) in Q3 were lower for both all-cause mortality (HR: 0.64, 95% CI: 0.43, 0.96) and CVD mortality (HR: 0.27, 95% CI: 0.09, 0.78). Preliminary meta-analysis also supported a similar U-shaped association of BRI with mortality with a HR in Q3 of 0.85 (95% CI: 0.75, 0.95) compared with Q1.</p><p><strong>Conclusions: </strong>BRI varies across age groups and between sexes in a Japanese population. Both our results and this meta-analysis suggest that BRI has U-shaped associations with all-cause and CVD mortality.</p><p><strong>Prospero registry no: </strong>1149845.</p>\",\"PeriodicalId\":16620,\"journal\":{\"name\":\"Journal of Nutrition\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nutrition\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tjnut.2025.09.031\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.tjnut.2025.09.031","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
Body roundness index and all-cause and cardiovascular mortality: findings from Japanese adults and preliminary meta-analysis.
Background: Although body roundness index (BRI) is gaining attention as an indicator of abdominal obesity, evidence on this indicator is still sparse.
Objective: We aimed to summarize basic information about BRI in a Japanese population and to examine associations of BRI with all-cause and cardiovascular disease (CVD) mortality with a preliminary meta-analysis.
Methods: This population-based cohort study included participants (mean age of 58.4 years [min, max: 40, 89], 37.8% men) in health check-up programs between 2004 and 2018, and we followed up until December 31, 2023. BRI was calculated by a conventional formula for height (cm) and waist circumference (cm). CVD mortality was defined as mortality with ICD-10 codes of I00-I99. Hazard ratios were estimated for all-cause and CVD mortality using Cox proportional hazards regression models.
Results: During the follow-up period (median: 13.3 years), 206 individuals died, and 47 individuals died from CVD. Women had a wider distribution of BRI (median: 3.72; IQR: 2.84, 4.88) compared with men (median: 3.54; IQR: 2.88, 4.19). BRI increased from the 40-49 age group (median: 3.24; IQR: 2.42, 4.08) to those over 70 years old (median: 4.22; IQR: 3.20, 5.32). Compared with Q1, HRs (95% CI) in Q3 were lower for both all-cause mortality (HR: 0.64, 95% CI: 0.43, 0.96) and CVD mortality (HR: 0.27, 95% CI: 0.09, 0.78). Preliminary meta-analysis also supported a similar U-shaped association of BRI with mortality with a HR in Q3 of 0.85 (95% CI: 0.75, 0.95) compared with Q1.
Conclusions: BRI varies across age groups and between sexes in a Japanese population. Both our results and this meta-analysis suggest that BRI has U-shaped associations with all-cause and CVD mortality.
期刊介绍：
The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.
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