{"title":"灵活性或承诺:在分裂和分化之间做出选择。","authors":"Pablo González-Suárez, Margot E Smit","doi":"10.1093/jxb/eraf429","DOIUrl":null,"url":null,"abstract":"<p><p>As cells move from acquiring a specific identity to gaining cell type-specific functions during differentiation, their properties and programs need to be adjusted. Initially, most newly specified cells show high division potential and properties that confer them qualities reminiscent of stem cells. During maturation, however, cells exit or change division programs and gain differentiation characteristics. Factors that regulate this progression have often been described to control either division or differentiation but are now more often being linked to both sides of this trade-off. In this review, we provide an overview of recent publications that identify some of the factors balancing division and differentiation. We discuss these in the context of the tissues and cell types they act in and note connections to cell cycle regulation. Recent advances are now allowing for a better understanding of how division and differentiation programs intertwine to shape cell trajectories.</p>","PeriodicalId":15820,"journal":{"name":"Journal of Experimental Botany","volume":" ","pages":""},"PeriodicalIF":5.7000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Flexibility or commitment: choosing between division and differentiation.\",\"authors\":\"Pablo González-Suárez, Margot E Smit\",\"doi\":\"10.1093/jxb/eraf429\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>As cells move from acquiring a specific identity to gaining cell type-specific functions during differentiation, their properties and programs need to be adjusted. Initially, most newly specified cells show high division potential and properties that confer them qualities reminiscent of stem cells. During maturation, however, cells exit or change division programs and gain differentiation characteristics. Factors that regulate this progression have often been described to control either division or differentiation but are now more often being linked to both sides of this trade-off. In this review, we provide an overview of recent publications that identify some of the factors balancing division and differentiation. We discuss these in the context of the tissues and cell types they act in and note connections to cell cycle regulation. Recent advances are now allowing for a better understanding of how division and differentiation programs intertwine to shape cell trajectories.</p>\",\"PeriodicalId\":15820,\"journal\":{\"name\":\"Journal of Experimental Botany\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Experimental Botany\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1093/jxb/eraf429\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PLANT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental Botany","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/jxb/eraf429","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
Flexibility or commitment: choosing between division and differentiation.
As cells move from acquiring a specific identity to gaining cell type-specific functions during differentiation, their properties and programs need to be adjusted. Initially, most newly specified cells show high division potential and properties that confer them qualities reminiscent of stem cells. During maturation, however, cells exit or change division programs and gain differentiation characteristics. Factors that regulate this progression have often been described to control either division or differentiation but are now more often being linked to both sides of this trade-off. In this review, we provide an overview of recent publications that identify some of the factors balancing division and differentiation. We discuss these in the context of the tissues and cell types they act in and note connections to cell cycle regulation. Recent advances are now allowing for a better understanding of how division and differentiation programs intertwine to shape cell trajectories.
期刊介绍:
The Journal of Experimental Botany publishes high-quality primary research and review papers in the plant sciences. These papers cover a range of disciplines from molecular and cellular physiology and biochemistry through whole plant physiology to community physiology.
Full-length primary papers should contribute to our understanding of how plants develop and function, and should provide new insights into biological processes. The journal will not publish purely descriptive papers or papers that report a well-known process in a species in which the process has not been identified previously. Articles should be concise and generally limited to 10 printed pages.