灵活性或承诺:在分裂和分化之间做出选择。

IF 5.7 2区 生物学 Q1 PLANT SCIENCES
Pablo González-Suárez, Margot E Smit
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引用次数: 0

摘要

当细胞在分化过程中从获得特定的身份到获得细胞类型特定的功能时,它们的特性和程序需要调整。最初,大多数新指定的细胞表现出高分裂潜能和特性,使它们具有干细胞的特性。然而,在成熟过程中,细胞退出或改变分裂程序并获得分化特征。调节这一进程的因素通常被描述为控制分裂或分化,但现在更多地与这种权衡的双方联系在一起。在这篇综述中,我们提供了最近的出版物的概述,确定了一些平衡分裂和分化的因素。我们在组织和细胞类型的背景下讨论这些,并注意到它们与细胞周期调节的联系。最近的进展使我们能够更好地理解分裂和分化程序是如何交织在一起形成细胞轨迹的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flexibility or commitment: choosing between division and differentiation.

As cells move from acquiring a specific identity to gaining cell type-specific functions during differentiation, their properties and programs need to be adjusted. Initially, most newly specified cells show high division potential and properties that confer them qualities reminiscent of stem cells. During maturation, however, cells exit or change division programs and gain differentiation characteristics. Factors that regulate this progression have often been described to control either division or differentiation but are now more often being linked to both sides of this trade-off. In this review, we provide an overview of recent publications that identify some of the factors balancing division and differentiation. We discuss these in the context of the tissues and cell types they act in and note connections to cell cycle regulation. Recent advances are now allowing for a better understanding of how division and differentiation programs intertwine to shape cell trajectories.

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来源期刊
Journal of Experimental Botany
Journal of Experimental Botany 生物-植物科学
CiteScore
12.30
自引率
4.30%
发文量
450
审稿时长
1.9 months
期刊介绍: The Journal of Experimental Botany publishes high-quality primary research and review papers in the plant sciences. These papers cover a range of disciplines from molecular and cellular physiology and biochemistry through whole plant physiology to community physiology. Full-length primary papers should contribute to our understanding of how plants develop and function, and should provide new insights into biological processes. The journal will not publish purely descriptive papers or papers that report a well-known process in a species in which the process has not been identified previously. Articles should be concise and generally limited to 10 printed pages.
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