自组装肽止血凝胶治疗eus引导引流和直接内镜下胰液坏死切除术出血的疗效和安全性。

IF 7.5 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastrointestinal endoscopy Pub Date : 2025-09-27 DOI:10.1016/j.gie.2025.09.046

Germana de Nucci, Vincenzo Colace, Giuseppe Fierro, Roberta Muscia, Raffaella Reati, Daniela Morganti, Maurizio Vecchi, Davide Bona, Gianpiero Manes

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引用次数: 0

摘要

背景与研究目的：eus引导下引流和直接内镜下坏死切除术（DEN）是治疗症状性假性囊肿和壁闭塞性胰腺坏死（WOPN）的主要方法。出血是与引流相关的严重不良事件，也是由于缺乏有效的内镜止血技术。Purastat在治疗胃肠道出血方面表现出优异的效果。我们的目的是评估这种止血凝胶治疗eus引导下引流和胰液收集DEN （pfc）继发性出血的有效性和安全性。患者和方法：在这项多中心、回顾性、观察性研究中，2017年至2024年期间，27例患者因pfc eus引导引流或WOPN DEN治疗期间或之后的活动性出血而接受了Purastat治疗。结果：共记录出血38次。出血类型为渗出型36例，喷射型2例。Purastat的应用成功率为100%，止血成功率为96.5%。结论：这种新型止血凝胶是一种安全有效的治疗pfc eus引导引流或DEN相关渗出性出血的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

EFFICACY AND SAFETY OF A SELF-ASSEMBLING PEPTIDE HAEMOSTATIC GEL IN THE TREATMENT OF BLEEDING IN EUS-GUIDED DRAINAGE AND DIRECT ENDOSCOPIC NECROSECTOMY OF PANCREATIC FLUID COLLECTIONS.

Background and study aim: EUS-guided drainage and direct endoscopic necrosectomy (DEN) are primary treatment modalities for symptomatic pseudocysts and walled-off pancreatic necrosis (WOPN). Bleeding is a serious adverse event associated with drainage, also due to lack of effective endoscopic haemostatic techniques. Purastat demonstrated excellent results to manage gastrointestinal bleeding. Our aim was to evaluate the efficacy and safety of this haemostatic gel in managing bleeding secondary to EUS-guided drainage and DEN of pancreatic fluid collections (PFCs).

Patients and methods: In this multicenter, retrospective, observational study 27 patients underwent Purastat treatment because of active bleeding during or after PFCs EUS-guided drainage or WOPN DEN sessions between 2017 and 2024.

Results: 38 bleeding episodes were recorded. The bleeding type was oozing in 36 cases and spurting in 2 cases. Purastat was successfully applied in 100% of patients and achieved successful haemostasis in 96.5% of cases.

Conclusions: This novel haemostatic gel is a safe andeffectiveto manage oozing bleedings related to PFCs EUS-guided drainage or DEN.

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来源期刊

Gastrointestinal endoscopy 医学-胃肠肝病学

CiteScore

10.30

自引率

7.80%

发文量

1441

审稿时长

38 days

期刊介绍： Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.