EMSY增强卵巢癌细胞的糖酵解。

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-29 DOI:10.1186/s40001-025-03133-x

Shaosheng Wang, Na Xie, Ping Zha, Yingming Li, Minghui Wei, Ji Bai, Xiaohong Zhao

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引用次数: 0

摘要

EMSY在卵巢癌的进展中至关重要；然而，其对肿瘤代谢的影响尚不清楚。研究表明，过表达EMSY的卵巢癌细胞产生更多的乳酸，并上调LDHA的表达；当卵巢癌细胞中的LDHA表达被敲低或糖酵解被抑制时，EMSY对这些细胞恶性表型的促进作用就被消除了。机制研究表明，EMSY与β-catenin相互作用，EMSY的下调抑制了β-catenin对LDHA的转录激活。综上所述，本研究确定了EMSY在卵巢癌细胞中的代谢调节作用，为卵巢癌的治疗提供了新的治疗靶点。

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EMSY enhances glycolysis in ovarian cancer cells.

EMSY is critical in the progression of ovarian cancer; nevertheless, its impact on tumor metabolism is not widely known. This study showed ovarian cancer cells overexpressing EMSY produce more lactate and have upregulated LDHA expression; the promoting effect of EMSY on the malignant phenotype of these cells is eliminated when LDHA expression is knocked down or glycolysis is inhibited in ovarian cancer cells. Mechanistic studies revealed that EMSY interacts with β-catenin, and the knockdown of EMSY inhibits the transcriptional activation of LDHA by β-catenin. In summary, this study identifies EMSY's metabolic regulatory role in ovarian cancer cells and offers treatment of ovarian cancer with a new therapeutic target.

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.