马来酰亚胺的2-安替吡林-、（5-硫氧-2,5-二氢- 1h -1,2,4-三唑）-6- yl -、（1,3,4-噻二唑-2- yl）-6-羧基酰胺-、6-硫脲-和6-肼基硫醇衍生物的体外抗氧化活性

IF 0.9 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-09-18 DOI:10.1007/s10600-025-04790-4

G. F. Vafina, T. A. Sapozhnikova, S. F. Gabdrakhmanova

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引用次数: 0

摘要

合成了含有苯基硫脲片段的马来海松酸衍生物。采用FRAP、DPPH自由基还原和ABTS自由基还原三种体外模型，研究了24种2位和6位马来海松酸衍生物的抗氧化活性。2-烯丙基马酰亚胺的甲基-、2-异烟碱-和2-（吡啶-3-羰基）肼基碳硫基衍生物在体外ABTS模型中的抗氧化活性与参比药抗坏血酸相当，优于Trolox。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antioxidant Activity in vitro of 2-Antipyrine-, (5-Thioxo-2,5-Dihydro-1H-1,2,4-Triazol)-6-YL-, (1,3,4-Thiadiazol-2-YL)-6-Carboxamide-, 6-Thioureide-, and 6-Hydrazinothiol Derivatives of Maleopimarimide

New derivatives of maleopimaric acid containing phenylthioureide fragments were synthesized. The antioxidant activity of 24 maleopimaric acid derivatives in the 2- and 6-positions was studied in three in vitro models, i.e., FRAP, reduction of DPPH radical, and reduction of ABTS radical. Methyl-, 2-isonicotinoyl-, and 2-(pyridin-3-ylcarbonyl)hydrazinocarbonothioyl derivatives of 2-allylmaleopimarimide showed antioxidant activity in vitro in the ABTS model comparable to the reference drug ascorbic acid and superior than that of Trolox.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.