研究c3 -甲基萘[1,2-b]呋喃-4,5-二酮类似物对抗癌活性的影响

IF 0.9 4区化学 Q4 CHEMISTRY, MEDICINAL

Chemistry of Natural Compounds Pub Date : 2025-09-18 DOI:10.1007/s10600-025-04782-4

Yue Zhu, Jia Yu, Xin Tan, Ni Zhang, Jin-Yu Li, Hua-Yong Lou, Heng Luo, Chao Chen, Wei-Dong Pan

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引用次数: 0

摘要

为了研究c3 -甲基取代萘[1,2-b]呋喃-4,5-二酮类似物对抗肿瘤效果的影响，合成了16种c3 -甲基化（TC1 -TC8）和c3 -去甲基化（TC1 ' -TC8 '）的NQO1底物类似物。对K562、LNCaP、HeLa和MDA-MB-231的抗癌活性表明，萘[1,2-b]呋喃-4,5-二酮类似物的甲基和去甲基衍生物具有相当的细胞毒性，这种值更多地取决于C-2位置取代基的性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Investigating the Impact of C3-Methyl of Naphtho[1,2-b]Furan-4,5-Dione Analogs for Anticancer Activity

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Investigating the Impact of C3-Methyl of Naphtho[1,2-b]Furan-4,5-Dione Analogs for Anticancer Activity

To investigate the impact of C3-methyl substitution of naphtho[1,2-b]furan-4,5-dione analogs on antitumor efficacy, 16 NQO1 substrate analogs of C3-methylated (TC1–TC8) and C3-demethylated (TC1′–TC8′) were synthesized. The anticancer activities against K562, LNCaP, HeLa, and MDA-MB-231 suggested that methyl and demethyl derivatives of naphtho[1,2-b]furan-4,5-dione analogs have comparable cytotoxicity and this value depends more on the nature of the substituent at position C-2.

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来源期刊

Chemistry of Natural Compounds 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

265

审稿时长

7.8 months

期刊介绍： Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.