Philipp Pfeiffer MD, Karen Wittemann, Edoardo Zancanaro MD, Vanessa Buchholz, Leon Mattern, Chris Probst MD, Franz Masseli MD, Ahmed Ghazy MD, Hendrik Treede MD, PhD, Daniel-Sebastian Dohle MD, PhD
{"title":"冷冻象鼻手术中远端吻合的近端定位","authors":"Philipp Pfeiffer MD, Karen Wittemann, Edoardo Zancanaro MD, Vanessa Buchholz, Leon Mattern, Chris Probst MD, Franz Masseli MD, Ahmed Ghazy MD, Hendrik Treede MD, PhD, Daniel-Sebastian Dohle MD, PhD","doi":"10.1016/j.xjtc.2025.06.010","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The frozen elephant trunk (FET) technique is frequently used in aortic arch diseases. Proximalization of the distal anastomosis from zone 3 to zone 2 results in shorter distal ischemia times and improved outcomes. This study assessed the impact of performing distal anastomoses progressively more proximally.</div></div><div><h3>Methods</h3><div>A total of 243 patients treated between March 2016 and December 2023 were identified using our institutional database, and relevant data were analyzed retrospectively. The patients were stratified according to the distal anastomosis zone, and perioperative and outcome variables were compared. A subgroup analysis was performed accordingly for patients with acute aortic dissections.</div></div><div><h3>Results</h3><div>Most of the 243 included patients (66%) were treated for acute dissection, followed by chronic dissection (24%) and thoracic aortic aneurysms (10%). The patients’ mean age was 62.5 ± 10.8 years, and 175 patients (72%) were male. The distal ischemia time was significantly reduced with the more proximal anastomoses: 24.5 minutes for zone 0 (69 patients), 37.4 minutes for zone 1 (18 patients), 30.4 minutes for zone 2 (145 patients), and 38.7 minutes for zone 3 (11 patients); <em>P</em> < .001. A longer cross-clamping time in zone 0 was explained by the higher number of root procedures, while other outcome parameters showed no significant differences. These same significant differences also were present in the acute dissection subgroup. In a separate analysis, a shorter duration of distal ischemia correlated with improved long-term survival (<em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>The FET technique with distal anastomosis in zone 2 is a reliable technique that produces good results. Proximalization of the distal anastomosis to zone 0 significantly reduces the ischemic burden and simplifies the procedure.</div></div>","PeriodicalId":53413,"journal":{"name":"JTCVS Techniques","volume":"33 ","pages":"Pages 38-50"},"PeriodicalIF":1.9000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Proximalization of the distal anastomosis in frozen elephant trunk surgery\",\"authors\":\"Philipp Pfeiffer MD, Karen Wittemann, Edoardo Zancanaro MD, Vanessa Buchholz, Leon Mattern, Chris Probst MD, Franz Masseli MD, Ahmed Ghazy MD, Hendrik Treede MD, PhD, Daniel-Sebastian Dohle MD, PhD\",\"doi\":\"10.1016/j.xjtc.2025.06.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The frozen elephant trunk (FET) technique is frequently used in aortic arch diseases. Proximalization of the distal anastomosis from zone 3 to zone 2 results in shorter distal ischemia times and improved outcomes. This study assessed the impact of performing distal anastomoses progressively more proximally.</div></div><div><h3>Methods</h3><div>A total of 243 patients treated between March 2016 and December 2023 were identified using our institutional database, and relevant data were analyzed retrospectively. The patients were stratified according to the distal anastomosis zone, and perioperative and outcome variables were compared. A subgroup analysis was performed accordingly for patients with acute aortic dissections.</div></div><div><h3>Results</h3><div>Most of the 243 included patients (66%) were treated for acute dissection, followed by chronic dissection (24%) and thoracic aortic aneurysms (10%). The patients’ mean age was 62.5 ± 10.8 years, and 175 patients (72%) were male. The distal ischemia time was significantly reduced with the more proximal anastomoses: 24.5 minutes for zone 0 (69 patients), 37.4 minutes for zone 1 (18 patients), 30.4 minutes for zone 2 (145 patients), and 38.7 minutes for zone 3 (11 patients); <em>P</em> < .001. A longer cross-clamping time in zone 0 was explained by the higher number of root procedures, while other outcome parameters showed no significant differences. These same significant differences also were present in the acute dissection subgroup. In a separate analysis, a shorter duration of distal ischemia correlated with improved long-term survival (<em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>The FET technique with distal anastomosis in zone 2 is a reliable technique that produces good results. Proximalization of the distal anastomosis to zone 0 significantly reduces the ischemic burden and simplifies the procedure.</div></div>\",\"PeriodicalId\":53413,\"journal\":{\"name\":\"JTCVS Techniques\",\"volume\":\"33 \",\"pages\":\"Pages 38-50\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JTCVS Techniques\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666250725002597\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JTCVS Techniques","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666250725002597","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Proximalization of the distal anastomosis in frozen elephant trunk surgery
Background
The frozen elephant trunk (FET) technique is frequently used in aortic arch diseases. Proximalization of the distal anastomosis from zone 3 to zone 2 results in shorter distal ischemia times and improved outcomes. This study assessed the impact of performing distal anastomoses progressively more proximally.
Methods
A total of 243 patients treated between March 2016 and December 2023 were identified using our institutional database, and relevant data were analyzed retrospectively. The patients were stratified according to the distal anastomosis zone, and perioperative and outcome variables were compared. A subgroup analysis was performed accordingly for patients with acute aortic dissections.
Results
Most of the 243 included patients (66%) were treated for acute dissection, followed by chronic dissection (24%) and thoracic aortic aneurysms (10%). The patients’ mean age was 62.5 ± 10.8 years, and 175 patients (72%) were male. The distal ischemia time was significantly reduced with the more proximal anastomoses: 24.5 minutes for zone 0 (69 patients), 37.4 minutes for zone 1 (18 patients), 30.4 minutes for zone 2 (145 patients), and 38.7 minutes for zone 3 (11 patients); P < .001. A longer cross-clamping time in zone 0 was explained by the higher number of root procedures, while other outcome parameters showed no significant differences. These same significant differences also were present in the acute dissection subgroup. In a separate analysis, a shorter duration of distal ischemia correlated with improved long-term survival (P = .002).
Conclusions
The FET technique with distal anastomosis in zone 2 is a reliable technique that produces good results. Proximalization of the distal anastomosis to zone 0 significantly reduces the ischemic burden and simplifies the procedure.